Document Detail

Exposure to glycol ethers in a population of French men evaluated by measurement of urinary alkoxycarboxylic acids.
MedLine Citation:
PMID:  15164289     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Glycol ethers are solvents that are present in a large number of products used commercially and domestically. During recent years, ethylene glycol ether derivatives, in particular ethylene glycol methyl ether and ethylene glycol ethyl ether, have been progressively replaced by propylene glycol ether derivatives, which are less toxic. The aim of this study was to estimate the level of exposure to glycol ethers in a sample population of French men employed by the Paris Municipality by measuring the amount of alkoxycarboxylic acid metabolites in their urine. METHODS: Urine samples were collected at the end of two different working weeks from 109 men, 54 of whom were judged to be occupationally exposed to glycol ether-containing products. Five alkoxyacetic acids (methoxyacetic, ethoxyacetic, n-propoxyacetic, phenoxyacetic, butoxyacetic acids) from ethylene glycol derivatives, and one alkoxypropionic acid (2-methoxypropionic) from a propylene glycol derivative, were simultaneously analysed by gas chromatography coupled to electron-capture detection. RESULTS: 2-Methoxypropionic was the most frequently found alkoxycarboxylic acid. The concentration of this metabolite reached 5.6 mmol/mol creatinine. The second most common alkoxycarboxylic acid was phenoxyacetic (up to 2.3 mmol/mol creatinine). The concentrations of the other alkoxycarboxylic acids were less than 1 mmol/mol creatinine. Although the concentration of alkoxycarboxylic acids was higher among men occupationally exposed to glycol ether-containing products than among unexposed men, the difference was significant only for butoxyacetic acid. CONCLUSIONS: Our data suggest that the use and exposure levels of glycol ethers have qualitatively and quantitatively changed dramatically over recent years. Particular attention should be paid in the future to alkoxypropionic acids derived from minor isomers of propylene glycol ether derivatives.
E Ben-Brik; L Jérôme; I Arnaud; S Yous; L Labat; J M Haguenoer; Luc Multigner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-05-26
Journal Detail:
Title:  International archives of occupational and environmental health     Volume:  77     ISSN:  0340-0131     ISO Abbreviation:  Int Arch Occup Environ Health     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-08     Completed Date:  2004-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512134     Medline TA:  Int Arch Occup Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  368-72     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Springer-Verlag
Service de Médecine Professionnelle et Préventive de la Ville de Paris, Paris, France.
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MeSH Terms
Carboxylic Acids / urine*
Environmental Pollutants / toxicity*
Ethylene Glycols / toxicity*
Middle Aged
Propylene Glycol / toxicity*
Solvents / toxicity*
Reg. No./Substance:
0/Carboxylic Acids; 0/Environmental Pollutants; 0/Ethylene Glycols; 0/Solvents; 57-55-6/Propylene Glycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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