Document Detail


Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice.
MedLine Citation:
PMID:  18094524     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF-induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D(1)-like receptor antagonist, but not with sulpiride, a dopaminergic D(2)-like receptor antagonist, inhibited ELF-MF-induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF-induced behavioral responses are, at least in part, mediated by activation of dopamine D(1)-like receptors.
Authors:
Eun-Joo Shin; Ji Hoon Jeong; Hyun Ji Kim; Choon-Gon Jang; Kiyofumi Yamada; Toshitaka Nabeshima; Hyoung-Chun Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmacological sciences     Volume:  105     ISSN:  1347-8613     ISO Abbreviation:  J. Pharmacol. Sci.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-20     Completed Date:  2008-05-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101167001     Medline TA:  J Pharmacol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  367-71     Citation Subset:  IM    
Affiliation:
Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Behavior, Animal / drug effects,  radiation effects*
Benzazepines / pharmacology
Blotting, Western
Corpus Striatum / drug effects,  metabolism,  radiation effects
Dopamine / metabolism
Dopamine Antagonists / pharmacology
Dose-Response Relationship, Radiation
Electromagnetic Fields*
Image Interpretation, Computer-Assisted / methods
Immunochemistry
Mice
Mice, Inbred ICR
Motor Activity / drug effects,  radiation effects*
Nucleus Accumbens / drug effects,  metabolism,  radiation effects
Proto-Oncogene Proteins c-fos / metabolism
Radio Waves
Receptors, Dopamine D1 / metabolism*
Sulpiride / pharmacology
Time Factors
Chemical
Reg. No./Substance:
0/Benzazepines; 0/Dopamine Antagonists; 0/Proto-Oncogene Proteins c-fos; 0/Receptors, Dopamine D1; 15676-16-1/Sulpiride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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