| Exposure to drinking water disinfection by-products and pregnancy loss. | |
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MedLine Citation:
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PMID: 16957027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous research has suggested that exposure to elevated levels of drinking water disinfection by-products (DBPs) may cause pregnancy loss. In 2000-2004, the authors conducted a study in three US locations of varying DBP levels and evaluated 2,409 women in early pregnancy to assess their tap water DBP concentrations, water use, other risk factors, and pregnancy outcome. Tap water concentrations were measured in the distribution system weekly or biweekly. The authors considered DBP concentration and ingested amount and, for trihalomethanes only, bathing/showering and integrated exposure that included ingestion. On the basis of 258 pregnancy losses, they did not find an increased risk of pregnancy loss in relation to trihalomethane, haloacetic acid, or total organic halide concentrations; ingested amounts; or total exposure. In contrast to a previous study, pregnancy loss was not associated with high personal trihalomethane exposure (> or =75 micro g/liter and > or =5 glasses of water/day) (odds ratio = 1.1, 95% confidence interval: 0.7, 1.7). Sporadic elevations in risk were found across DBPs, most notably for ingested total organic halide (odds ratio = 1.5, 95% confidence interval: 1.0, 2.2 for the highest exposure quintile). These results provide some assurance that drinking water DBPs in the range commonly encountered in the United States do not affect fetal survival. |
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Authors:
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David A Savitz; Philip C Singer; Amy H Herring; Katherine E Hartmann; Howard S Weinberg; Christina Makarushka |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2006-09-06 |
Journal Detail:
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Title: American journal of epidemiology Volume: 164 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-20 Completed Date: 2007-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 1043-51 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC, USA. david.savitz@mssm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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chemically induced*,
epidemiology* Adult Data Interpretation, Statistical Disinfectants / adverse effects* Environmental Exposure Female Humans Hydrocarbons, Halogenated / adverse effects*, analysis Pregnancy Pregnancy Outcome / epidemiology* Risk Factors Trihalomethanes / adverse effects*, analysis United States / epidemiology Water Pollutants, Chemical / adverse effects*, analysis Water Purification / methods* Water Supply* |
| Chemical | |
Reg. No./Substance:
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0/Disinfectants; 0/Hydrocarbons, Halogenated; 0/Trihalomethanes; 0/Water Pollutants, Chemical |
| Comments/Corrections | |
Comment In:
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Am J Epidemiol. 2006 Dec 1;164(11):1052-5
[PMID:
16957028
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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