Document Detail


Exposure to diethylstilbestrol during pregnancy permanently alters the ovary and oviduct.
MedLine Citation:
PMID:  6850046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the effects of transplacental exposure to diethylstilbestrol (DES) on the ovary and oviduct of the CD-1 mouse, timed pregnant mice were injected subcutaneously with DES (100 micrograms/kg) on Days 9 through 16 of gestation and female offspring sacrificed from 4 weeks to 10 months of age. Following DES exposure, ovarian alterations such as inflammation, a prominent interstitial compartment composed of medullary tubule-like structures, and intra- and para-ovarian cysts from mesonephric remnants were observed. In addition, there were oviductal abnormalities including malformation. As reported previously, the oviduct was closely adherent and coiled around the ovary in a similar position to that seen in the fetal mouse. This malformation was termed developmental arrest of the oviduct (DAO) and was a consistent finding in female offspring exposed prenatally to DES (100 micrograms/kg). Increased prevalence of salpingitis and microscopic alterations in the oviduct were also observed. Oviductal epithelium was mostly secretory type with basal vacuoles. In some cases, oviductal epithelium was hyperplastic and formed mucosal folds resembling glands which extended through the muscularis (diverticulosis). The extent of the adenomatous mucosal folds and the degree of extension through the muscularis increased with the age of the animal (100% at 10 months). Some characteristics of this abnormality resembled salpingitis isthmica nodosa, a lesion described in women which is associated with ectopic pregnancies and subfertility. Gross and microscopic changes in the oviduct were more consistent than were the changes among other portions of the reproductive tract of DES-treated mice previously reported. Since subfertility has been described in this mouse model as well as in prenatally DES-exposed women, the data presented in this report may help in evaluation of the reported reduced fertility in exposed patients as well as other infertility patients.
Authors:
R R Newbold; B C Bullock; J A Mc Lachlan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of reproduction     Volume:  28     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  735-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Diethylstilbestrol / toxicity*
Fallopian Tubes / abnormalities,  drug effects*,  pathology
Female
Fetus / drug effects*
Hyperplasia
Mice
Ovarian Cysts / chemically induced
Ovarian Neoplasms / chemically induced
Ovary / abnormalities,  drug effects*,  pathology
Pregnancy
Prenatal Exposure Delayed Effects
Chemical
Reg. No./Substance:
56-53-1/Diethylstilbestrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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