| Exposure to diesel exhaust exacerbates allergen-induced airway responses in guinea pigs. | |
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MedLine Citation:
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PMID: 11734452 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diesel exhaust (DE) is a major air pollutant in urban areas. To clarify the effects of DE on the exacerbation of asthma, guinea pigs were exposed 12 h daily to 3 mg/m(3) DE or air for 8 wk with or without sensitization to ovalbumin (OVA). In the DE-exposed sensitized animals, both immediate (IAR) and late (LAR) airway responses were enhanced after the inhalation challenge by OVA, compared with the DE-unexposed sensitized animals. Mucus was greatly accumulated in the airways of DE-exposed sensitized animals during IAR. The number of eosinophils and level of sialic acid concentration in bronchial lavage fluids were also significantly higher in the DE-exposed sensitized animals than in the DE-unexposed control animals. During LAR, intercellular spaces of the bronchial epithelium became enlarged in the DE-exposed sensitized animals, showing infiltration by numerous eosinophils. Albumin concentration was significantly higher in the bronchial lavage fluids from the DE-exposed sensitized animals than in those from the DE-unexposed control animals. These results suggest that exposure to DE enhances mucus hypersecretion and eosinophilic inflammation during IAR. DE exposure also increases airway permeability and airway inflammation during LAR. Thus, DE exposure exacerbates allergen-induced airway responses in guinea pigs. |
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Authors:
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K Hashimoto; Y Ishii; Y Uchida; T Kimura; K Masuyama; Y Morishima; K Hirano; A Nomura; T Sakamoto; H Takano; M Sagai; K Sekizawa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 164 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-12-05 Completed Date: 2002-01-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1957-63 Citation Subset: AIM; IM |
Affiliation:
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Department of Respiratory Medicine, University of Tsukuba, Ibaraki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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adverse effects* Analysis of Variance Animals Asthma / blood, etiology*, immunology, pathology Bronchial Provocation Tests Bronchoalveolar Lavage Fluid / chemistry, cytology, immunology Disease Models, Animal* Eosinophils / immunology Female Guinea Pigs Immunoglobulin E / blood, immunology Immunoglobulin G / blood, immunology Inflammation Inhalation Exposure / adverse effects* Leukocyte Count Mucus / physiology N-Acetylneuraminic Acid / analysis Ovalbumin / diagnostic use, immunology Time Factors Vehicle Emissions / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Immunoglobulin G; 0/Vehicle Emissions; 131-48-6/N-Acetylneuraminic Acid; 37341-29-0/Immunoglobulin E; 9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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