Document Detail


Exposure to diesel exhaust exacerbates allergen-induced airway responses in guinea pigs.
MedLine Citation:
PMID:  11734452     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diesel exhaust (DE) is a major air pollutant in urban areas. To clarify the effects of DE on the exacerbation of asthma, guinea pigs were exposed 12 h daily to 3 mg/m(3) DE or air for 8 wk with or without sensitization to ovalbumin (OVA). In the DE-exposed sensitized animals, both immediate (IAR) and late (LAR) airway responses were enhanced after the inhalation challenge by OVA, compared with the DE-unexposed sensitized animals. Mucus was greatly accumulated in the airways of DE-exposed sensitized animals during IAR. The number of eosinophils and level of sialic acid concentration in bronchial lavage fluids were also significantly higher in the DE-exposed sensitized animals than in the DE-unexposed control animals. During LAR, intercellular spaces of the bronchial epithelium became enlarged in the DE-exposed sensitized animals, showing infiltration by numerous eosinophils. Albumin concentration was significantly higher in the bronchial lavage fluids from the DE-exposed sensitized animals than in those from the DE-unexposed control animals. These results suggest that exposure to DE enhances mucus hypersecretion and eosinophilic inflammation during IAR. DE exposure also increases airway permeability and airway inflammation during LAR. Thus, DE exposure exacerbates allergen-induced airway responses in guinea pigs.
Authors:
K Hashimoto; Y Ishii; Y Uchida; T Kimura; K Masuyama; Y Morishima; K Hirano; A Nomura; T Sakamoto; H Takano; M Sagai; K Sekizawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  164     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-05     Completed Date:  2002-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1957-63     Citation Subset:  AIM; IM    
Affiliation:
Department of Respiratory Medicine, University of Tsukuba, Ibaraki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Allergens / adverse effects*
Analysis of Variance
Animals
Asthma / blood,  etiology*,  immunology,  pathology
Bronchial Provocation Tests
Bronchoalveolar Lavage Fluid / chemistry,  cytology,  immunology
Disease Models, Animal*
Eosinophils / immunology
Female
Guinea Pigs
Immunoglobulin E / blood,  immunology
Immunoglobulin G / blood,  immunology
Inflammation
Inhalation Exposure / adverse effects*
Leukocyte Count
Mucus / physiology
N-Acetylneuraminic Acid / analysis
Ovalbumin / diagnostic use,  immunology
Time Factors
Vehicle Emissions / adverse effects*
Chemical
Reg. No./Substance:
0/Allergens; 0/Immunoglobulin G; 0/Vehicle Emissions; 131-48-6/N-Acetylneuraminic Acid; 37341-29-0/Immunoglobulin E; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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