| Exposure to diagnostic radiological procedures and the risk of childhood acute lymphoblastic leukemia. | |
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MedLine Citation:
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PMID: 20861400 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Diagnostic irradiation of the mother during pregnancy increases the risk of childhood acute lymphoblastic leukemia (ALL). There is inconsistent evidence on associations between ALL and other parental or childhood diagnostic irradiation. The aim of this analysis is to investigate whether diagnostic X-rays of the mother before birth, of the father before conception, or of the child increased the risk of childhood ALL. METHODS: Data from 389 cases and 876 frequency-matched controls were analyzed using unconditional logistic regression, adjusting for study matching factors and potential confounders. A meta-analysis of our findings in relation to paternal X-rays before conception with the published findings of previous studies was also conducted. RESULTS: There was no evidence of an increased risk with maternal abdominal X-rays before the birth of the index child or with the child having any X-rays more than 6 months before the censoring date. The odds ratio (OR) for any paternal abdominal X-ray before conception was 1.17 [95% confidence interval (95% CI), 0.88-1.55], and 1.47 (95% CI, 0.98-2.21) for more than one X-ray. The OR for any paternal intravenous pyelogram before conception was 3.56 (95% CI, 1.59-7.98). The pooled OR for this study with previous studies of any paternal abdominal X-rays before conception was 1.17 (95% CI, 0.92-1.48). CONCLUSIONS: There was some evidence of an increased risk of ALL in the offspring if the father had more than one abdominal X-ray before conception or had ever had an intravenous pyelogram. IMPACT: We plan to repeat this analysis by using pooled data to improve precision. |
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Authors:
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Helen D Bailey; Bruce K Armstrong; Nicholas H de Klerk; Lin Fritschi; John Attia; Liane Lockwood; Elizabeth Milne; |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-22 |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 19 ISSN: 1538-7755 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 2897-909 Citation Subset: IM |
Copyright Information:
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©2010 AACR. |
Affiliation:
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Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, WA, Australia. helenb@ichr.uwa.edu.au |
Export Citation:
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Descriptor/Qualifier:
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| Investigator | |
Investigator/Affiliation:
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Bruce K Armstrong / ; Elizabeth Milne / ; Frank M van Bockxmeer / ; Michelle Haber / ; Rodney J Scott / ; John Attia / ; Murray D Norris / ; Carol Bower / ; Nicholas H de Klerk / ; Lin Fritschi / ; Ursula R Kees / ; Margaret Miller / ; Judith R Thompson / ; Helen D Bailey / ; Frank Alvaro / ; Catherine Cole / ; Luciano Dalla Pozza / ; John Daubenton / ; Peter Downie / ; Liane Lockwood / ; Maria Kirby / ; Glenn Marshall / ; Elizabeth Smibert / ; Ram Suppiah / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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