Document Detail


Exposure to cooking oil fumes and oxidative damages: a longitudinal study in Chinese military cooks.
MedLine Citation:
PMID:  22968348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cooking oil fumes (COF) contain polycyclic aromatic hydrocarbons (PAHs), heterocyclic aromatic amines, benzene, and formaldehyde, which may cause oxidative damages to DNA and lipids. We assessed the relations between exposure to COF and subsequent oxidative DNA damage and lipid peroxidation among military cooks and office-based soldiers. The study population, including 61 Taiwanese male military cooks and a reference group of 37 office soldiers, collected urine samples pre-shift of the first weekday and post-shift of the fifth workday. We measured airborne particulate PAHs in military kitchens and offices and concentrations of urinary 1-OHP, a biomarker of PAH exposure, urinary 8-hydroxydeoxyguanosine (8-OHdG), a biomarkers of oxidative DNA damage, and urinary isoprostane (Isop). Airborne particulate PAHs levels in kitchens significantly exceeded those in office areas. The concentrations of urinary 1-OHP among military cooks increased significantly after 5 days of exposure to COF. Using generalized estimating equation analysis adjusting for confounding, a change in log(8-OHdG) and log(Isop) were statistically significantly related to a unit change in log(1-OHP) (regression coefficient (β), β=0.06, 95% CI 0.001-0.12) and (β=0.07, 95% CI 0.001-0.13), respectively. Exposure to PAHs, or other compounds in cooking oil fumes, may cause both oxidative DNA damage and lipid peroxidation.
Authors:
Ching-Huang Lai; Jouni J K Jaakkola; Chien-Yi Chuang; Saou-Hsing Liou; Shih-Chun Lung; Ching-Hui Loh; Dah-Shyong Yu; Paul T Strickland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-12
Journal Detail:
Title:  Journal of exposure science & environmental epidemiology     Volume:  23     ISSN:  1559-064X     ISO Abbreviation:  J Expo Sci Environ Epidemiol     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-06-05     Revised Date:  2014-05-23    
Medline Journal Info:
Nlm Unique ID:  101262796     Medline TA:  J Expo Sci Environ Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  94-100     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Air Pollution, Indoor*
China
Cooking*
DNA Damage
Deoxyguanosine / analogs & derivatives,  urine
Humans
Longitudinal Studies
Male
Military Personnel*
Occupational Exposure*
Oils*
Oxidative Stress*
Polycyclic Compounds / toxicity
Pyrenes / urine
Young Adult
Grant Support
ID/Acronym/Agency:
P30 CA006973/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Oils; 0/Polycyclic Compounds; 0/Pyrenes; 5315-79-7/1-hydroxypyrene; 88847-89-6/8-oxo-7-hydrodeoxyguanosine; G9481N71RO/Deoxyguanosine
Comments/Corrections

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