Document Detail


Exposure to behaviourally relevant odour reveals differential characteristics in rat central olfactory pathways as studied through oscillatory activities.
MedLine Citation:
PMID:  11015328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated how changes in nutritional motivation modulate odour-related oscillatory activities at several levels of the olfactory pathway in non-trained rats. Local field potential recordings were obtained in freely moving animals in the olfactory bulb (OB), anterior and posterior parts of the piriform cortex (APC and PPC respectively) and lateral entorhinal cortex (EC). Dynamic signal analysis detected changes in power during odour presentation for several frequency bands The results showed that in most cases odour presentation was associated with changes in a wide 15-90 Hz frequency band of activity in each olfactory structure. However, nutritional state modulated initial responses to food odour (FO) in the OB and EC selectively in the 15-30 Hz frequency band. Changes in nutritional state also modulated responses to repeated FO stimuli. Habituation was expressed differentially across structures with a clear dissociation between the two parts of the piriform cortex. Finally, systemic injections of scopolamine (0.125 mg/kg) selectively blocked expression of the nutritional modulation in the OB found in the beta band. These results suggest that internal state can differentially modulate odour processing among different olfactory areas and point to a cholinergic-sensitive beta band oscillation during presentation of a behaviourally meaningful odorant.
Authors:
P Chabaud; N Ravel; D A Wilson; A M Mouly; M Vigouroux; V Farget; R Gervais
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical senses     Volume:  25     ISSN:  0379-864X     ISO Abbreviation:  Chem. Senses     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-30     Completed Date:  2000-11-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8217190     Medline TA:  Chem Senses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  561-73     Citation Subset:  IM    
Affiliation:
Institut des Sciences Cognitives, CNRS-UPR 9075, 67 Boulevard Pinel, F-69675 Bron, France. chabaud@isc.cnrs.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Male
Odors*
Olfactory Pathways / physiology*
Rats
Rats, Wistar
Smell / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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