Document Detail

Exposure to altered gravity affects all stages of endochondral cartilage differentiation.
MedLine Citation:
PMID:  11542628     Owner:  NASA     Status:  MEDLINE    
Chondrogenesis has a number of well-defined steps: (1) condensation, which involves cell aggregation, adhesion and communication; (2) activation of cartilage genes, which is accompanied by rounding up of the cells and intracellular differentiation; and (3) production and secretion of cartilage specific matrix molecules. Our studies show that each of these steps is affected by exposure to gravitational changes. Clinorotation and centrifugation affected initial aggregation and condensation. In the CELLS experiment, where cells were exposed to microgravity after some condensation occurred preflight, intracellular differentiation and matrix production were delayed relative to controls. Once cartilage has developed, in rats, further differentiation (hypertrophy, matrix production) was also affected by spaceflight and hind limb suspension. For the process of chondrogenesis to proceed as we know it, loading and other factors present at 1g are required at each step of the process. This requirement means that not only will skeletal development and bone healing, processes involving chondrogenesis, be altered by long term exposure to microgravity, but that continuous intervention will be necessary to correct any defects produced by altered gravity environments.
P J Duke; D Montufar-Solis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Advances in space research : the official journal of the Committee on Space Research (COSPAR)     Volume:  24     ISSN:  0273-1177     ISO Abbreviation:  Adv Space Res     Publication Date:  1999  
Date Detail:
Created Date:  2000-02-29     Completed Date:  2000-02-29     Revised Date:  2007-04-16    
Medline Journal Info:
Nlm Unique ID:  9878935     Medline TA:  Adv Space Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  821-7     Citation Subset:  S    
The University of Texas-Houston Health Science Center, Orthodontics and Dentofacial Orthopedics 77030, USA.
Space Flight Mission:
Cosmos Project; Flight Experiment; STS Shuttle Project; manned; short duration; unmanned
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MeSH Terms
Bone Development*
Bone and Bones / cytology,  embryology
Cartilage / cytology,  embryology*,  growth & development
Chondrogenesis / physiology*
Growth Plate / blood supply,  cytology,  embryology,  growth & development
Space Flight*
P J Duke / U TX Health Sci Ctr, Houston

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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