Document Detail


Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth.
MedLine Citation:
PMID:  25282280     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Preterm birth is an important marker of health and has a prevalence of 12-13% in the U.S. Polycyclic aromatic hydrocarbons (PAHs) are a group of organic contaminants that form during the incomplete combustion of hydrocarbons, such as coal, diesel and gasoline. Studies suggest that exposure to PAHs during pregnancy is related to adverse birth outcomes. The aim of this study is to evaluate the association between exposure to PAHs during the pregnancy and preterm birth.
METHODS: The study population included births from years 2001 to 2006 of women whose maternal residence was within 20km of the primary monitoring site in Fresno, California. Data in the Fresno area were used to form a spatio-temporal model to assign daily exposure to PAHs with 4, 5, or 6 rings at the maternal residence throughout pregnancy of all of the births in the study area. Gestational age at birth and relevant covariates were extracted from the birth certificate.
RESULTS: We found an association between PAHs during the last 6 weeks of pregnancy and birth at 20-27 weeks (OR=2.74; 95% CI: 2.24-3.34) comparing the highest quartile to the lower three. The association was consistent when each quartile was compared to the lowest (OR2nd=1.49, 95% CI: 1.08-2.06; OR3rd=2.63, 95% CI:1.93-3.59; OR4th=3.94, 95% CI:3.03-5.12). Inverse associations were also observed for exposure to PAHs during the entire pregnancy and the first trimester and birth at 28-31 weeks and 20-27 weeks.
CONCLUSION: An association between PAH exposure during the 6 weeks before delivery and early preterm birth was observed. However, the inverse association with early preterm birth offers an unclear, and potentially complex, inference of these associations.
Authors:
Amy M Padula; Elizabeth M Noth; S Katharine Hammond; Fred W Lurmann; Wei Yang; Ira B Tager; Gary M Shaw
Publication Detail:
Type:  Journal Article     Date:  2014-10-02
Journal Detail:
Title:  Environmental research     Volume:  135     ISSN:  1096-0953     ISO Abbreviation:  Environ. Res.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-09     Completed Date:  -     Revised Date:  2014-12-09    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  221-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
K99 ES021470/ES/NIEHS NIH HHS; L40 ES023163/ES/NIEHS NIH HHS; P01 ES022849/ES/NIEHS NIH HHS; P20 ES018173/ES/NIEHS NIH HHS

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