Document Detail


Exposure to air pollution in critical prenatal time windows and IgE levels in newborns.
MedLine Citation:
PMID:  20609135     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The objective of this study was to analyze the mechanisms by which exposure to ambient air pollutants influences respiratory health may include altered prenatal immune development. To analyze associations between elevated cord serum Immunoglobulin E (IgE) levels and maternal air pollution exposure during each month of gestation. Total cord serum IgE was determined by the CAP system and mothers' total IgE levels by nephelometry for 459 births in the Czech Republic from May 1994 to mid-January 1997. Concentrations of polycyclic aromatic hydrocarbons (PAHs) and particulate matter <2.5 microns in diameter (PM(2.5) ) were measured in ambient air, and arithmetic means were calculated for each gestational month. Log binomial regression models were used to estimate prevalence ratios (PR) for elevated cord serum IgE (≥0.9 IU/ml) adjusting for district of residence, year of birth, and in further models, for maternal IgE (a surrogate for atopy) and gestational season. Heterogeneity by maternal atopy status was evaluated for associations of air pollution and of cigarette smoke. In adjusted models, PAH and PM(2.5) exposures in the second month of gestation were each associated with a lower prevalence of elevated cord serum IgE. For an average increase of 100 ng/m(3) of PAHs, the PR was 0.69 (95% confidence interval (CI): 0.50, 0.95); for 25 μg/m(3) increase in PM(2.5) , the PR was 0.77 (95% CI: 0.55, 1.07). Conversely, exposures later in gestation were associated with a higher prevalence of elevated cord IgE: in the fifth month, the PR for PAH exposure was 1.64 (95% CI: 1.29, 2.08), while for PM(2.5) in the sixth month, it was 1.66 (95% CI: 1.30, 2.13). In analyses stratified by maternal atopy, air pollutants were associated with altered cord serum IgE only among neonates with non-atopic mothers. Similarly, an association of cigarette smoke with elevated cord serum IgE was found only in non-atopic mothers. PAHs and PM(2.5) , constituents of both ambient air pollution and cigarette smoke, appear to influence fetal immune development, particularly among infants whose mothers are not atopic.
Authors:
Caroline E W Herr; Rakesh Ghosh; Miroslav Dostal; Venuse Skokanova; Paul Ashwood; Michael Lipsett; Jesse P Joad; Kent E Pinkerton; Poh-Sin Yap; Joshua D Frost; Radim Sram; Irva Hertz-Picciotto
Related Documents :
12093955 - Maternal bone lead as an independent risk factor for fetal neurotoxicity: a prospective...
17337925 - Spinal capillary hemangioma in infants: report of two cases and review of the literature.
19223155 - Mao-a and comt genotypes as possible regulators of perinatal serotonergic symptoms afte...
9259915 - Doppler velocimetry and nonstress test for predicting outcome of pregnancies with decre...
18171445 - Early weaning is related to weight and rate of weight gain in infancy.
14501545 - Development of behaviors in preterm infants: relation to sleeping and waking.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  22     ISSN:  1399-3038     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-84     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Affiliation:
Department of Public Health Sciences, Division of Epidemiology, University of California-Davis, CA 95616, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effects of NOS1 gene on asthma and total IgE levels in Taiwanese children, and the interactions ...
Next Document:  Specific IgE of common foods in Chinese children with eczema.