| Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. | |
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MedLine Citation:
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PMID: 20581459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Severe hypoxia has been demonstrated to induce a replication arrest which is associated with decreased levels of nucleotides. Chk1 is rapidly phosphorylated in response to severe hypoxia and in turn deactivates TLK1 through phosphorylation. Loss of Chk1 has been shown to sensitize cells to hypoxia/reoxygenation. After short (acute) exposure to hypoxia this is due to an increased rate of reoxygenation-induced replication restart and subsequent p53-dependent apoptosis. After longer (chronic) exposure to hypoxia S phase cells do not undergo reoxygenation-induced replication restart. Cells exposed to these levels of hypoxia however are sensitive to loss of Chk1. This suggests a new role for Chk1 in the cell cycle response to reoxygenation. |
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Authors:
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Isabel M Pires; Zuzana Bencokova; Chris McGurk; Ester M Hammond |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 9 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2011-04-18 Completed Date: 2011-06-15 Revised Date: 2012-09-18 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 2502-7 Citation Subset: IM |
Copyright Information:
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© 2010 Landes Bioscience |
Affiliation:
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The Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Hypoxia
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drug effects DNA Damage* DNA Repair / drug effects DNA Replication / drug effects Models, Biological Oxygen / pharmacology Phosphorylation / drug effects Protein Kinases / metabolism* Protein-Serine-Threonine Kinases / metabolism* Rad51 Recombinase / metabolism Signal Transduction / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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C6515/A9321//Cancer Research UK |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen; EC 2.7.-/Protein Kinases; EC 2.7.11.1/Checkpoint kinase 1; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 2.7.7.-/Rad51 Recombinase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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