Document Detail

Exposure to potentially toxic hydrocarbons and halocarbons released from the dialyzer and tubing set during hemodialysis.
MedLine Citation:
PMID:  22507911     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although much is known about the effect of chronic kidney failure and dialysis on the composition of solutes in plasma, little is known about their impact on the composition of gaseous compounds in exhaled breath. This study was designed to explore the effect of uremia and the hemodialysis (HD) procedure on the composition of exhaled breath. Breath samples were collected from 10 dialysis patients immediately before, during, and after a dialysis session. To determine the potential introduction of gaseous compounds from dialysis components, gasses emitted from dialyzers, tubing set, dialysate, and water supplies were collected.
STUDY DESIGN: Prospective cohort study.
PARTICIPANTS: 10 HD patients and 10 age-matched healthy individuals.
PREDICTOR: Predictors include the dialyzers, tubing set, dialysate, and water supplies before, during, and after dialysis.
OUTCOMES: Changes in the composition of exhaled breath.
MEASUREMENTS: A 5-column/detector gas chromatography system was used to measure hydrocarbon, halocarbon, oxygenate, and alkyl nitrate compounds.
RESULTS: Concentrations of 14 hydrocarbons and halocarbons in patients' breath rapidly increased after the onset of the HD treatment. All 14 compounds and 5 others not found in patients' breath were emitted from the dialyzers and tubing sets. Contrary to earlier reports, exhaled breath ethane concentrations in our dialysis patients were virtually unchanged during the HD treatment.
LIMITATIONS: Single-center study with a small sample size may limit the generalizability of the findings.
CONCLUSIONS: The study documented the release of several potentially toxic hydrocarbons and halocarbons to patients from the dialyzer and tubing sets during the HD procedure. Because long-term exposure to these compounds may contribute to the morbidity and mortality in dialysis population, this issue should be considered in the manufacturing of the new generation of dialyzers and dialysis tubing sets.
Hyun Ji Julie Lee; Simone Meinardi; Madeleine V Pahl; Nostratola D Vaziri; Donald R Blake
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-14
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  60     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-18     Completed Date:  2013-01-01     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  609-16     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Breath Tests
Chromatography, Gas
Hydrocarbons / analysis*
Kidney Failure, Chronic / metabolism*
Oxidative Stress / physiology
Prospective Studies
Renal Dialysis*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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