| Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitochondrial DNA in primary cultured neurons. | |
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MedLine Citation:
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PMID: 19879861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increasing evidence indicates that oxidative stress may be involved in the adverse effects of radiofrequency (RF) radiation on the brain. Because mitochondrial DNA (mtDNA) defects are closely associated with various nervous system diseases and mtDNA is particularly susceptible to oxidative stress, the purpose of this study was to determine whether radiofrequency radiation can cause oxidative damage to mtDNA. In this study, we exposed primary cultured cortical neurons to pulsed RF electromagnetic fields at a frequency of 1800 MHz modulated by 217 Hz at an average special absorption rate (SAR) of 2 W/kg. At 24 h after exposure, we found that RF radiation induced a significant increase in the levels of 8-hydroxyguanine (8-OHdG), a common biomarker of DNA oxidative damage, in the mitochondria of neurons. Concomitant with this finding, the copy number of mtDNA and the levels of mitochondrial RNA (mtRNA) transcripts showed an obvious reduction after RF exposure. Each of these mtDNA disturbances could be reversed by pretreatment with melatonin, which is known to be an efficient antioxidant in the brain. Together, these results suggested that 1800 MHz RF radiation could cause oxidative damage to mtDNA in primary cultured neurons. Oxidative damage to mtDNA may account for the neurotoxicity of RF radiation in the brain. |
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Authors:
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Shangcheng Xu; Zhou Zhou; Lei Zhang; Zhengping Yu; Wei Zhang; Yuan Wang; Xubu Wang; Maoquan Li; Yang Chen; Chunhai Chen; Mindi He; Guangbin Zhang; Min Zhong |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-30 |
Journal Detail:
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Title: Brain research Volume: 1311 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 189-96 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Occupational Health, Third Military Medical University, No 30 Gaotanyan Street, Shapingba District, Chongqing 400038, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology Cells, Cultured DNA Damage / drug effects, radiation effects* DNA, Mitochondrial / drug effects, radiation effects* Electromagnetic Fields / adverse effects Gene Dosage / drug effects, radiation effects Guanine / analogs & derivatives, metabolism Melatonin / pharmacology Mitochondria / drug effects, physiology, radiation effects* Neocortex / drug effects, physiology, radiation effects Neurons / drug effects, physiology, radiation effects* Oxidative Stress / drug effects, physiology, radiation effects* Radio Waves / adverse effects* Rats Rats, Sprague-Dawley Reactive Oxygen Species / metabolism, radiation effects Transcription, Genetic / drug effects, radiation effects |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/DNA, Mitochondrial; 0/Reactive Oxygen Species; 5614-64-2/8-hydroxyguanine; 73-31-4/Melatonin; 73-40-5/Guanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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