| Exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDT) in relation to bone mineral density and rate of bone loss in menopausal women. | |
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MedLine Citation:
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PMID: 11128875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The organochlorine pesticide 2,2-bis(p-chlorophenyl)-1,1,1,-trichloroethane (DDT) and its metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) are examples of an environmental contaminant that may have hormonal properties. Bone metabolism is both estrogen- and androgen-dependent. Exposures to various environmental endocrine disrupters can affect bone metabolism in animals, but there are no published data concerning the effect of DDE exposure on bone metabolism in humans. We hypothesized that high levels of DDE would be associated with lower bone density in peri- and postmenopausal women than in premenopausal women. Study subjects were drawn from the cohort of women who had participated in the Mount Sinai Medical Center Longitudinal Normative Bone Density Study (1984-1987). We used serum samples obtained at study entry to measure DDE levels in 103 (50 black, 53 white) women (mean age = 54.5 y [standard deviation = 5 y]). Measurements of bone mineral density at the lumbar spine and radius were made at 6-mo intervals during a 2-y period. DDE concentrations were significantly (p < .001) higher in blacks (13.9 ng/ml) than in whites (8.4 ng/ml), but there was no correlation between DDE concentration and bone density at the spine (mean levels = 1.065 g/cm2 and 1.043 g/cm2 in the lowest and highest quartiles, respectively, of DDE [trend p value = .85]) or at the radius (mean levels = 0.658 g/cm and 0.664 g/cm in the lowest and highest quartiles, respectively, of DDE [trend p value = .34]). Longitudinal analyses revealed no correlation between DDE and the rate of bone loss at either bone site. Similar results were seen in race-stratified analyses, as well as in analyses in which we controlled for lactation history and other potential confounders. We found little evidence that chronic low-level DDT exposure is associated with bone density in peri- and postmenopausal women. |
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Authors:
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A D Bohannon; G S Cooper; M S Wolff; D E Meier |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of environmental health Volume: 55 ISSN: 0003-9896 ISO Abbreviation: Arch. Environ. Health Publication Date: 2000 Nov-Dec |
Date Detail:
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Created Date: 2000-12-20 Completed Date: 2001-01-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0212627 Medline TA: Arch Environ Health Country: United States |
Other Details:
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Languages: eng Pagination: 386-91 Citation Subset: AIM; IM |
Affiliation:
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National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon African Continental Ancestry Group Bone Density / drug effects* Cohort Studies DDT / adverse effects*, blood* Environmental Pollutants / adverse effects* European Continental Ancestry Group Female Humans Linear Models Longitudinal Studies Menopause Middle Aged Osteoporosis, Postmenopausal / chemically induced*, diagnosis, ethnology Probability |
| Grant Support | |
ID/Acronym/Agency:
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1-ES 35357/ES/NIEHS NIH HHS; 5P60AG11268/AG/NIA NIH HHS; M01-RR00030/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 50-29-3/DDT |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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