| Exposure time and ventricular remodeling induced by tobacco smoke exposure in rats. | |
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MedLine Citation:
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PMID: 18301351 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We investigated the effects of length of exposure to tobacco smoke on the cardiac remodeling process induced by exposure to cigarette smoke in rats. MATERIAL/METHODS: Rats were separated into 4 groups: nonsmoking (NS)2 (n=25; control animals not exposed to tobacco smoke for 2 months), smoking (S)2 (n=22; rats exposed to smoke from 40 cigarettes/d for 2 months), NS6 (n=18; control animals not exposed to tobacco smoke for 6 months), and S6 (n=25; rats exposed to smoke from 40 cigarettes/d for 6 months). All animals underwent echocardiographic, isolated heart, and morphometric studies. Data were analyzed with a 2-way analysis of variance. RESULTS: No interaction among the variables was found; this suggests that length of exposure to tobacco smoke did not influence the effects of exposure to smoke. Values for left ventricular diastolic diameter/body weight and left atrium/body weight were higher (p=0.023 and p=0.001, respectively) in smoking (S2 and S6) than in nonsmoking animals (NS2 and NS6). Left ventricular mass index was higher (p=0.048) in smoking than in nonsmoking animals. In the isovolumetrically beating ventricle, peak systolic pressure was higher (p=0.034) in smoking than in nonsmoking animals. Significantly higher values were found for left ventricular weight (p=0.017) and right ventricular weight (p=0.001) adjusted for body weight in smoking as opposed to nonsmoking animals. Systolic pressure was higher (p=0.001) in smoking (128+/-14 mm Hg) than in nonsmoking animals (112+/-11 mm Hg). CONCLUSIONS: Length of exposure to cigarette smoke did not influence cardiac remodeling caused by exposure to smoke in rats. |
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Authors:
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Edson Castardeli; Daniella R Duarte; Marcos F Minicucci; Paula S Azevedo; Beatriz B Matsubara; Luiz S Matsubara; Alvaro O Campana; Sergio A R Paiva; Leonardo A M Zornoff |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 14 ISSN: 1234-1010 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-27 Completed Date: 2008-08-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: BR62-66 Citation Subset: IM |
Affiliation:
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Internal Medicine Department, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Male Rats Rats, Wistar Smoking / adverse effects* Ventricular Function, Left Ventricular Function, Right Ventricular Remodeling* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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