| Exposure-response relations for work related respiratory symptoms and sensitisation in a cohort exposed to alpha-amylase. | |
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MedLine Citation:
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PMID: 15150397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To explore relations between exposure to fungal alpha-amylase and the risk of new work related respiratory symptoms or sensitisation. METHODS: A prospective cohort study among 300 bakers and millers was followed up for a maximum of seven years. Exposure to alpha-amylase was estimated by air measurements and questionnaires and classified into three categories. Symptoms were recorded with a self-administered questionnaire and skin sensitisation assessed using skin prick test (SPT). RESULTS: There were 36 new cases of chest symptoms, 86 of eyes/nose symptoms, and 24 of a positive SPT to alpha-amylase. There were exposure-response relations for chest and eyes/nose symptoms and for sensitisation, and a significantly increased prevalence ratio for chest symptoms in the highest exposure category. CONCLUSION: A reduction in alpha-amylase exposure is likely to reduce the risk for respiratory morbidity in bakery workers. |
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Authors:
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J Brisman; M J Nieuwenhuijsen; K M Venables; V Putcha; S Gordon; A J N Taylor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Occupational and environmental medicine Volume: 61 ISSN: 1470-7926 ISO Abbreviation: Occup Environ Med Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-19 Completed Date: 2004-06-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9422759 Medline TA: Occup Environ Med Country: England |
Other Details:
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Languages: eng Pagination: 551-3 Citation Subset: IM |
Affiliation:
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Department of Occupational and Environmental Medicine, Imperial College (NHLI), London SW3 6LR, UK. jonas.brisman@ymk.gu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cohort Studies Dust Flour / analysis* Food-Processing Industry Humans Hypersensitivity, Immediate / etiology Occupational Diseases / etiology* Occupational Exposure / adverse effects* Prospective Studies Respiratory Hypersensitivity / etiology Skin Tests / methods alpha-Amylases / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Dust; EC 3.2.1.1/alpha-Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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