Document Detail

Exposure of flight attendants to pyrethroid insecticides on commercial flights: urinary metabolite levels and implications.
MedLine Citation:
PMID:  21937269     Owner:  NLM     Status:  MEDLINE    
Pyrethroid insecticides have been used for disinsection of commercial aircrafts. However, little is known about the pyrethroids exposure of flight attendants. The objective of the study was to assess pyrethroids exposure of flight attendants working on commercial aircrafts through monitoring the urinary pyrethroids metabolite levels. Eighty four urine samples were collected from 28 flight attendants, 18-65 years of age, with seventeen working on planes that were non-disinsected, and eleven working on planes that had been disinsected. Five urinary metabolites of pyrethroids were measured using gas chromatographic-mass spectrometric method: 3-phenoxybenzoic acid (3-PBA), cis-/trans-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclo-propane carboxylic acid (cis-/trans-Cl2CA), cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclo-propane-1-carboxylic acid (cis-Br2CA) and 4-fluoro-3-phenoxybenzoic acid (4F-3-PBA). Flight attendants working on disinsected planes had significantly higher urinary levels of 3-PBA, cis- and trans-Cl2CA in pre, post- and 24-h-post flight samples than those on planes which did not report having been disinsected. Urinary levels of cis-Br2CA and 4F-3-PBA did not show significant differences between the two groups. Flight attendants working on international flights connected to Australia had higher urinary levels of 3-PBA, cis- and trans-Cl2CA than those on either domestic and other international flights flying among Asia, Europe and North America. Post-disinsection duration (number of days from disinsection date to flight date) was the most significant factor affecting the urinary pyrethroid metabolites levels of 3-PBA, cis- and trans-Cl2CA of the group flying on disinsected aircraft. It was concluded that working on commercial aircraft disinsected by pyrethroids resulted in elevated body burdens of 3-PBA, cis- and trans-Cl2CA.
Binnian Wei; Krishnan R Mohan; Clifford P Weisel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-09-21
Journal Detail:
Title:  International journal of hygiene and environmental health     Volume:  215     ISSN:  1618-131X     ISO Abbreviation:  Int J Hyg Environ Health     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-09-19     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  100898843     Medline TA:  Int J Hyg Environ Health     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  465-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier GmbH. All rights reserved.
Exposure Science, Graduate School of Biomedical Science, Environmental and Occupational Health Sciences Institute, A Joint Institute of Rutgers University and University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA.
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MeSH Terms
Air Pollutants / urine*
Air Pollution, Indoor / analysis*,  statistics & numerical data
Environmental Monitoring / methods*
Insecticides / urine*
Middle Aged
North America
Occupational Exposure / analysis*,  statistics & numerical data
Pyrethrins / urine*
Young Adult
Grant Support
Reg. No./Substance:
0/Air Pollutants; 0/Insecticides; 0/Pyrethrins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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