Document Detail


Exposure and effect assessment of aerosolized red tide toxins (brevetoxins) and asthma.
MedLine Citation:
PMID:  19654919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In previous studies we demonstrated statistically significant changes in reported symptoms for lifeguards, general beach goers, and persons with asthma, as well as statistically significant changes in pulmonary function tests (PFTs) in asthmatics, after exposure to brevetoxins in Florida red tide (Karenia brevis bloom) aerosols.
OBJECTIVES: In this study we explored the use of different methods of intensive ambient and personal air monitoring to characterize these exposures to predict self-reported health effects in our asthmatic study population.
METHODS: We evaluated health effects in 87 subjects with asthma before and after 1 hr of exposure to Florida red tide aerosols and assessed for aerosolized brevetoxin exposure using personal and ambient samplers.
RESULTS: After only 1 hr of exposure to Florida red tide aerosols containing brevetoxin concentrations > 57 ng/m(3), asthmatics had statistically significant increases in self-reported respiratory symptoms and total symptom scores. However, we did not see the expected corresponding changes in PFT results. Significant increases in self-reported symptoms were also observed for those not using asthma medication and those living >/= 1 mile from the coast.
CONCLUSIONS: These results provide additional evidence of health effects in asthmatics from ambient exposure to aerosols containing very low concentrations of brevetoxins, possibly at the lower threshold for inducing a biologic response (i.e., toxicity). Consistent with the literature describing self-reported symptoms as an accurate measure of asthmatic distress, our results suggest that self-reported symptoms are a valuable measure of the extent of health effects from exposure to aerosolized brevetoxins in asthmatic populations.
Authors:
Lora E Fleming; Judy A Bean; Barbara Kirkpatrick; Yung Sung Cheng; Richard Pierce; Jerome Naar; Kate Nierenberg; Lorraine C Backer; Adam Wanner; Andrew Reich; Yue Zhou; Sharon Watkins; Mike Henry; Julia Zaias; William M Abraham; Janet Benson; Amy Cassedy; Julie Hollenbeck; Gary Kirkpatrick; Tainya Clarke; Daniel G Baden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2009-04-13
Journal Detail:
Title:  Environmental health perspectives     Volume:  117     ISSN:  1552-9924     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-08-05     Completed Date:  2009-10-08     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1095-100     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aerosols / toxicity
Aged
Asthma / pathology*
Enzyme-Linked Immunosorbent Assay
Female
Florida
Humans
Inhalation Exposure*
Male
Marine Toxins / toxicity*
Mass Spectrometry
Middle Aged
Oxocins / toxicity*
Young Adult
Grant Support
ID/Acronym/Agency:
1 P50 ES12736/ES/NIEHS NIH HHS; P01 ES010594/ES/NIEHS NIH HHS; P01 ES010594-09/ES/NIEHS NIH HHS; P01 ES10594/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Aerosols; 0/Marine Toxins; 0/Oxocins; 98225-48-0/brevetoxin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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