Document Detail

Exposure of consumers to morphine from poppy seeds in Hungary.
MedLine Citation:
PMID:  22165856     Owner:  NLM     Status:  Publisher    
Poppy seed-containing foods are popular dishes in Hungary and some other Central European countries. The alkaloids of poppy are used in the production of medicines. Poppy seeds used as food may also contain considerable amounts of alkaloids, which raises the question of food safety. Morphine, codeine, thebaine and noscapine concentrations of poppy seed samples from the period 2001-2010 and consumption data from two Hungarian surveys, carried out in 2003 and 2009, were evaluated. Exposure calculations were made for morphine intake by both point estimate and probabilistic methods, and the uncertainty of the calculated values was estimated. The point estimate for the acute consumer exposure, calculated using the 97.5th percentiles of morphine concentration and of poppy seed consumption and taking into account the reduction of morphine content by processing, was 78.64 µg (kg bw)(-1 )day(-1) for adults, and 116.90 µg (kg bw)(-1 )day(-1) for children. Based on probabilistic estimations, the 97.5th and 99th percentile exposures ranged between 18.3-25.4 and 25.6-47.4 µg (kg bw)(-1 )day(-1) for adults, and between 32.9 and 66.4 µg (kg bw)(-1 )day(-1) for children, respectively. As a no observed effect level (NOEL) had not been established, the significance of exposure could not be assessed.
A Zentai; J Sali; M Szeitzné-Szabó; I J Szabó; A Ambrus
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-10
Journal Detail:
Title:  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     Volume:  -     ISSN:  1944-0057     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485040     Medline TA:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Hungarian Food Safety Office , Budapest 1097, Gyáli út 2-6 , Hungary.
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