Document Detail

Exposure of chronic obstructive pulmonary disease patients to particles: respiratory and cardiovascular health effects.
MedLine Citation:
PMID:  11791165     Owner:  NLM     Status:  MEDLINE    
To examine hypotheses regarding air pollution health effects, we conducted an exploratory study to evaluate relationships between personal and ambient concentrations of particles with measures of cardiopulmonary health in a sample of patients with chronic obstructive pulmonary disease (COPD). Sixteen currently non-smoking COPD patients (mean age=74) residing in Vancouver were equipped with a particle (PM(2.5)) monitor for seven 24-h periods. Subjects underwent ambulatory heart monitoring, had their lung function and blood pressure (BP) measured, and recorded symptoms and medication use. Ambient PM(2.5), PM(10), sulfate, and gaseous pollutant concentrations were monitored at five sites within the study area. Although no associations between air pollution and lung function were statistically significant, an estimated effect of 3% and 1% declines in daily FEV(1) change (DeltaFEV(1)) for each 10 microg/m(3) increase in ambient PM(10) and PM(2.5), respectively, was observed. Increases of 1 microg/m(3) in personal or ambient sulfate were associated with 1.0% and 0.3% declines in DeltaFEV(1), respectively. Weak associations were observed between particle concentrations and increased supraventricular ectopic heartbeats and with decreased systolic BP. No consistent associations were observed between any particle metric and diastolic BP, heart rate, or heart rate variability (r-MSSD or SDNN), symptom severity, or bronchodilator use. Of the pollutants measured, ambient PM(10) was most consistently associated with health parameters; the use of personal exposures did not improve the strength of any associations or lead to increased effect estimates.
M Brauer; S T Ebelt; T V Fisher; J Brumm; A J Petkau; S Vedal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of exposure analysis and environmental epidemiology     Volume:  11     ISSN:  1053-4245     ISO Abbreviation:  J Expo Anal Environ Epidemiol     Publication Date:    2001 Nov-Dec
Date Detail:
Created Date:  2002-01-15     Completed Date:  2002-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111438     Medline TA:  J Expo Anal Environ Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490-500     Citation Subset:  IM    
School of Occupational and Environmental Hygiene, The University of British Columbia, Vancouver, Canada.
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MeSH Terms
Air Pollutants / adverse effects*
Blood Pressure
Cardiovascular Diseases / etiology*
Environmental Exposure*
Epidemiologic Studies
Heart Rate
Lung Diseases / etiology*
Middle Aged
Particle Size
Pulmonary Disease, Chronic Obstructive / epidemiology,  etiology*
Respiratory Function Tests
Sulfates / adverse effects
Reg. No./Substance:
0/Air Pollutants; 0/Sulfates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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