Document Detail

Exponential model for a regulatory enzyme. Computer program for the determination of the model constants from initial velocity data.
MedLine Citation:
PMID:  3583437     Owner:  NLM     Status:  MEDLINE    
The paper describes a program (DESCENT) which evaluates the constants of the exponential model for a regulatory enzyme with up to four substrates or up to three substrates and one effector. The program operates by repetitive adjustment of the model constants so as to secure a better fit between the observed and calculated initial velocities of reaction. At each adjustment, all the constants are incremented simultaneously by amounts determined by a steepest descent criterion. The program is tested by artificial data with and without added error and it is shown that good estimates of the constants can be recovered.
S Ainsworth; J Kinderlerer; N Rhodes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of bio-medical computing     Volume:  20     ISSN:  0020-7101     ISO Abbreviation:  Int. J. Biomed. Comput.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-07-09     Completed Date:  1987-07-09     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0252005     Medline TA:  Int J Biomed Comput     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  163-73     Citation Subset:  IM    
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MeSH Terms
Allosteric Regulation
Enzyme Induction
Models, Theoretical

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