Document Detail

Exponential analysis of the pressure-volume characteristics of ovine lungs.
MedLine Citation:
PMID:  8059069     Owner:  NLM     Status:  MEDLINE    
Static pressure-volume curves were generated from data obtained from 18 normal anaesthetized adult sheep. Lung volumes were determined by helium dilution. An exponential curve of the form V = Vmax - Ae-KP was fitted to the pressure-volume data from each sheep where P is the static recoil pressure, Vmax represents the volume asymptote, A is the difference between Vmax and the intercept on the volume axis and K defines the slope and hence the shape of the P-V curve. Quality of fit of the data was assessed visually, by means of a sign test and a runs test and by the coefficient of determination (r2). Exponential equations were found to adequately describe the shape of the pressure-volume curve in sheep. The exponent K was not correlated with effective alveolar volume (VAeff) (rs = 0.183; P > 0.05). Static lung compliance was determined over a volume range from the end-expiratory level (VEEL) to VEEL plus 400 ml. Measurements of static lung compliance were significantly correlated with measurements of effective alveolar volume (VAeff) (rs = 0.505; P < 0.025). In the ovine, the exponent K, an index of distensibility, is independent of lung volume and offers a means of assessing lung distensibility in this species.
D D Collie; N J Watt; P M Warren; I Begara; L Luján
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  95     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-09-15     Completed Date:  1994-09-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  239-47     Citation Subset:  IM    
Royal (Dick) School of Veterinary Studies, Veterinary Field Station, Roslin, Midlothian, UK.
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MeSH Terms
Air Pressure*
Lung / anatomy & histology,  physiology*
Lung Compliance / physiology
Lung Volume Measurements
Respiratory Mechanics / physiology
Sheep / physiology*
Total Lung Capacity / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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