Document Detail

Exploring tick saliva: from biochemistry to 'sialomes' and functional genomics.
MedLine Citation:
PMID:  15938506     Owner:  NLM     Status:  MEDLINE    
Tick saliva, a fluid once believed to be only relevant for lubrication of mouthparts and water balance, is now well known to be a cocktail of potent anti-haemostatic, anti-inflammatory and immunomodulatory molecules that helps these arthropods obtain a blood meal from their vertebrate hosts. The repertoire of pharmacologically active components in this cocktail is impressive as well as the number of targets they specifically affect. These salivary components change the physiology of the host at the bite site and, consequently, some pathogens transmitted by ticks take advantage of this change and become more infective. Tick salivary proteins have therefore become an attractive target to control tick-borne diseases. Recent advances in molecular biology, protein chemistry and computational biology are accelerating the isolation, sequencing and analysis of a large number of transcripts and proteins from the saliva of different ticks. Many of these newly isolated genes code for proteins with homologies to known proteins allowing identification or prediction of their function. However, most of these genes code for proteins with unknown functions therefore opening the road to functional genomic approaches to identify their biological activities and roles in blood feeding and hence, vaccine development to control tick-borne diseases.
J G Valenzuela
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Parasitology     Volume:  129 Suppl     ISSN:  0031-1820     ISO Abbreviation:  Parasitology     Publication Date:  2004  
Date Detail:
Created Date:  2005-06-07     Completed Date:  2006-07-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401121     Medline TA:  Parasitology     Country:  England    
Other Details:
Languages:  eng     Pagination:  S83-94     Citation Subset:  IM    
Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, 4 Center Drive, 4/B2-35, Bethesda, MD 20892, USA.
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MeSH Terms
Anti-Inflammatory Agents / metabolism
Anticoagulants / metabolism
Arachnid Vectors / chemistry,  genetics,  physiology*
Bites and Stings / immunology*
Host-Parasite Interactions
Platelet Aggregation Inhibitors / metabolism
Saliva / chemistry,  immunology,  physiology
Salivary Proteins and Peptides / genetics,  immunology*
Tick-Borne Diseases / prevention & control*,  transmission
Ticks / chemistry,  genetics,  physiology*
Vaccination / methods
Vaccines / classification
Vasodilator Agents / metabolism
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anticoagulants; 0/Platelet Aggregation Inhibitors; 0/Salivary Proteins and Peptides; 0/Vaccines; 0/Vasodilator Agents

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