| Exploring the relationship between perceived inter-dose opioid withdrawal and patient characteristics in methadone maintenance treatment. | |
| | |
MedLine Citation:
|
PMID: 19713051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Despite clinical optimization of methadone doses, as many as 53% of patients experience significant and unacceptable levels inter-dose opioid withdrawal some of the time. Little is known about the relationship between perceived inter-dose opioid withdrawal and patient characteristics in methadone maintenance treatment. METHODS: Ninety stabilized MMT patients were recruited and divided into three satisfaction groups (holders (H), partial holders (PH), and nonholders (NH)) based on their perceived opioid withdrawal as assessed by a guided self-report process. A battery of subjective assessments was administered during the approximate trough methadone condition. The primary measures were the Subjective Opioid Withdrawal Scale (SubOWS), Hopkins Symptom Checklist-90 (SCL-90), Obsessive-Compulsive Drug Use Survey (OCDUS), Profile of Mood States (POMS), and Neo Personality Inventory (NEO). RESULTS: Nonholders experienced more opioid withdrawal (SubOWS-NH: 22.0+/-8.8 vs. PH: 12.2+/-8.2 vs. H: 9.3+/-10.0, p<0.001) and craving (OCDUS-NH: 11.4+/-8.8 vs. PH: 6.4+/-6.9 vs. H: 6.5+/-6.2, p=0.016). Holders experienced less Obsessive/Compulsive psychological distress (SCL-90-NH: 15.3+/-8.1 vs. PH: 12.3+/-7.3 vs. H: 6.6+/-5.1, p<0.001), Depression/Dejection (POMS-NH: 19.7+/-13.7 vs. PH: 17.2+/-13.2 vs. H: 7.9+/-10.4, p=0.002), and neurotic personality (NEO-NH: 63.3+/-12.3 vs. PH: 60.9+/-10.0 vs. H: 54.0+/-8.8, p=0.006). Partial holders had a less agreeable personality (NEO-NH: 44.2+/-8.6 vs. PH: 38.0+/-10.6 vs. H: 47.6+/-11.7, p=0.002). CONCLUSIONS: Physical opioid withdrawal is an important factor in understanding patient satisfaction with MMT. However, patient characteristics, such as level of psychological distress and negative mood, may also need to be considered because of their relationship with perceived inter-dose opioid withdrawal symptoms and patient satisfaction. |
| | |
Authors:
|
Alex K Elkader; Bruna Brands; Russell Callaghan; Beth A Sproule |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2009-08-26 |
Journal Detail:
|
Title: Drug and alcohol dependence Volume: 105 ISSN: 1879-0046 ISO Abbreviation: Drug Alcohol Depend Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-10-19 Completed Date: 2010-01-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7513587 Medline TA: Drug Alcohol Depend Country: Ireland |
Other Details:
|
Languages: eng Pagination: 209-14 Citation Subset: IM |
Affiliation:
|
Centre for Addiction and Mental Health, 33 Russell St., Toronto, ON, Canada M5S 2S1. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Affect Anxiety Behavior, Addictive / psychology Female Humans Male Methadone / therapeutic use Opioid-Related Disorders / drug therapy, psychology* Pain / psychology Patient Satisfaction Personality Stress, Psychological Substance Withdrawal Syndrome / diagnosis, psychology* Time Factors |
| Chemical | |
Reg. No./Substance:
|
76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An unusual self-limited clonal Mott cell proliferation with lymphoplasmacytic lymphoma-like features...
Next Document: HPA axis response to psychological stress and treatment retention in residential substance abuse tre...