| Exploring the potential of low doses carbon monoxide as therapy in pregnancy complications. | |
| | |
MedLine Citation:
|
PMID: 22348450 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
Heme Oxygenase-1 (HO-1) has been shown to play a pivotal role in pregnancy outcome and its ablation leads to abnormal placentation, intrauterine fetal growth restriction (IUGR) and subsequent intrauterine fetal death. Carbon monoxide (CO) has been found to mimic the protective effects of HO-1 activity, rescuing HO-1-deficient fetuses. This gasotransmitter arises in biological systems during the oxidative catabolism of heme by HO. Here, we explored the potential of CO in preventing IUGR and established the optimal doses and therapeutic time window in a clinically relevant mouse model. We additionally investigated the pathways activated upon CO application in vivo. We established 50 ppm as the best lowest dose of CO necessary to prevent growth restriction being the optimal time frame during days 3 to 8 of mouse pregnancy. CO lead to higher fetal and placental weights and avoided fetal death without showing any pathologic effects. CO breathing further suppressed inflammatory responses, diminished placenta apoptosis and complement deposition and regulated placental angiogenesis. Our results confirm the protective role of the HO-1/CO axis and point this gas as an emerging therapeutic possibility which is worth to further explore. |
| | |
Authors:
|
Tarek El-Mousleh; Pablo A Casalis; Ivonne Wollenberg; Maria L Zenclussen; Hans D Volk; Stefanie Langwisch; Federico Jensen; Ana C Zenclussen |
Publication Detail:
|
Type: Journal Article Date: 2012-02-20 |
Journal Detail:
|
Title: Medical gas research Volume: 2 ISSN: 2045-9912 ISO Abbreviation: Med Gas Res Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-03-23 Completed Date: 2012-10-02 Revised Date: 2012-11-09 |
Medline Journal Info:
|
Nlm Unique ID: 101564536 Medline TA: Med Gas Res Country: England |
Other Details:
|
Languages: eng Pagination: 4 Citation Subset: - |
Affiliation:
|
Department of Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany. ana.zenclussen@med.ovgu.de. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nocturnal Oximetry and Transcutaneous Carbon Dioxide in Home-Ventilated Neuromuscular Patients.
Next Document: Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adult...