Document Detail


Exploring physical activity level in patients with thoracic cancer: implications for use as an outcome measure.
MedLine Citation:
PMID:  22311375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Cachexia is common in patients with thoracic cancer impairing physical function and quality of life. New approaches which target muscle tissue are emerging and activity monitors could provide an objective assessment of their effect on physical function. We have collated data from three studies involving the use of one such monitor in order to benchmark aspects of physical activity for patients with thoracic cancer, explore how these relate to physician-rated performance status, and consider the implications for future studies.
METHODS: Patients with thoracic cancer and an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0-2 wore an ActivPAL™ monitor for 1 week. The mean time spent each day in a range of activities, e.g. standing or stepping, or their frequency, e.g. number of sit-to-stand transitions, steps taken, were calculated and compared according to ECOG PS.
RESULTS: Data from 84 patients (54 male; mean (SD) age, 66 (9) years) were collated. Each day, patients spent a mean (SD) of 4.3 (2.0) h upright, completed 45 (17) sit-to-stand transitions and took 4,246 (2,983) steps. There was wide variation in each activity examined. All but the number of sit-to-stand transitions differed significantly between ECOG PS categories.
CONCLUSIONS: These data provide a detailed insight into how physical activity levels decline across the range of ECOG PS categories studied. The wide variation in physical activity within each ECOG PS category suggests that this scale may lack sufficient sensitivity to evaluate new cachexia treatments. Our data help to inform future work in this area.
Authors:
Matthew Maddocks; Andrew Wilcock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-05
Journal Detail:
Title:  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer     Volume:  20     ISSN:  1433-7339     ISO Abbreviation:  Support Care Cancer     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-03-27     Completed Date:  2012-07-19     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  9302957     Medline TA:  Support Care Cancer     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1113-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cachexia / etiology,  physiopathology*
Female
Humans
Male
Middle Aged
Motor Activity / physiology*
Outcome Assessment (Health Care)*
Quality of Life
Thoracic Neoplasms / pathology*
Time Factors
Grant Support
ID/Acronym/Agency:
C18598/A8211//Cancer Research UK; PDF-2011-04-048//Department of Health

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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