Document Detail

Exploring the cell uptake mechanism of phospholipid and polyethylene glycol coated gold nanoparticles.
MedLine Citation:
PMID:  22222168     Owner:  NLM     Status:  In-Data-Review    
Recently, there has been a lot of interest in using gold nanoparticles (GNPs) for biomedical applications due to their biocompatibility. To increase GNP cell uptake and circulation half-life, and to improve its bio-distribution in vivo, we chose to coat GNPs with 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) (POPG) and polyethylene glycol (PEG). Two different methods were used to synthesize POPG-GNPs or PEG-GNPs, but the resulting nanoparticle sizes and morphologies were similar. Under the same incubation conditions, POPG-GNPs can be uptaken quicker than PEG-GNPs by cells-specifically, the maximum uptake was 8 h versus 16 h after incubation. In addition, the uptake amount of POPG-GNPs was more than that of PEG-GNPs. The uptake processes were confirmed by SEM and TEM images. The main reason for the greater uptake of POPG-GNPs can be attributed to the structural similarities between the POPG coating and the cell membrane as well as GNP aggregation.
Yuzhi Hao; Xiaoyang Yang; Steven Song; Min Huang; Chuan He; Mingyang Cui; Jie Chen
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Publication Detail:
Type:  Journal Article     Date:  2012-01-06
Journal Detail:
Title:  Nanotechnology     Volume:  23     ISSN:  1361-6528     ISO Abbreviation:  Nanotechnology     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101241272     Medline TA:  Nanotechnology     Country:  England    
Other Details:
Languages:  eng     Pagination:  045103     Citation Subset:  IM    
Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada. Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada. National Institute for Nanotechnology, Edmonton, AB, Canada. School of Chemical Engineering, Hebei University of Technology, Tianjin, People's Republic of China.
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