| Exploring the cell uptake mechanism of phospholipid and polyethylene glycol coated gold nanoparticles. | |
| | |
MedLine Citation:
|
PMID: 22222168 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Recently, there has been a lot of interest in using gold nanoparticles (GNPs) for biomedical applications due to their biocompatibility. To increase GNP cell uptake and circulation half-life, and to improve its bio-distribution in vivo, we chose to coat GNPs with 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) (POPG) and polyethylene glycol (PEG). Two different methods were used to synthesize POPG-GNPs or PEG-GNPs, but the resulting nanoparticle sizes and morphologies were similar. Under the same incubation conditions, POPG-GNPs can be uptaken quicker than PEG-GNPs by cells-specifically, the maximum uptake was 8 h versus 16 h after incubation. In addition, the uptake amount of POPG-GNPs was more than that of PEG-GNPs. The uptake processes were confirmed by SEM and TEM images. The main reason for the greater uptake of POPG-GNPs can be attributed to the structural similarities between the POPG coating and the cell membrane as well as GNP aggregation. |
| | |
Authors:
|
Yuzhi Hao; Xiaoyang Yang; Steven Song; Min Huang; Chuan He; Mingyang Cui; Jie Chen |
Related Documents
:
|
16163608 - Asymmetric cell divisions in flowering plants - one mother, "two-many" daughters. 11856178 - Estimation of directional division frequencies in vascular cambium and in marginal meri... 8056318 - Mutation load under vegetative reproduction and cytoplasmic inheritance. 10231488 - Ftsz ring clusters in min and partition mutants: role of both the min system and the nu... 10810288 - Insulin-like growth factor ii in human fetal pancreas and its co-localization with the ... 15147518 - Choline availability modulates human neuroblastoma cell proliferation and alters the me... |
Publication Detail:
|
Type: Journal Article Date: 2012-01-06 |
Journal Detail:
|
Title: Nanotechnology Volume: 23 ISSN: 1361-6528 ISO Abbreviation: Nanotechnology Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101241272 Medline TA: Nanotechnology Country: England |
Other Details:
|
Languages: eng Pagination: 045103 Citation Subset: IM |
Affiliation:
|
Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada. Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada. National Institute for Nanotechnology, Edmonton, AB, Canada. School of Chemical Engineering, Hebei University of Technology, Tianjin, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The epidemiology of injury for an elite junior Australian Football cohort.
Next Document: Ureteral stents placed at the time of urinary diversion decreases postoperative morbidity.