Document Detail


Exploring associations between serum levels of select organochlorines and thyroxine in a sample of New York state sportsmen: the New York State Angler Cohort Study.
MedLine Citation:
PMID:  12865048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This preliminary study investigated associations between environmental organochlorine compounds and thyroid function in a sample of 66 sportsmen selected from among participants in the New York State Angler Cohort Study. A cross-sectional design was employed with the primary goal of the analysis being the generation of specific testable hypotheses. Blood samples were analyzed for compounds based on a priori identified literature-cited evidence of thyroid disruption. These included hexachlorobenzene and polychlorinated biphenyl congeners 19, 28, 47, 118, 153, 169, 180, 183, and 187. Time of sample collection, serum triglycerides, cholesterol, high- and low-density lipoproteins, age, body mass index, and cigarette smoking were considered for each participant. Potential associations between organochlorine compounds and serum total thyroxine, controlling for potential confounders, were examined using multivariable linear regression models. The models reported consisted of all variates being entered ("full" model, R2=0.380, P=0.136) and stepwise selection of variates ("reduced" models, alpha=0.15) using the criterion of maximum partial correlation at each step. Several procedures were considered to address contaminant data below the limit of detection in the reduced models with no change in selected predictors. Hexachlorobenzene (beta=-0.113) and age (beta=0.007) were selected as predictors of serum T4 in the reduced models (R2=0.083, P=0.065). Power analysis suggested that by doubling the sample size the existing results would be statistically significant with a type I error of 0.05 and a power of 0.80. These findings are important in the design of a new specific study of thyroid function and environmental contaminants.
Authors:
Michael S Bloom; John M Weiner; John E Vena; Gregory P Beehler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental research     Volume:  93     ISSN:  0013-9351     ISO Abbreviation:  Environ. Res.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-07-16     Completed Date:  2003-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52-66     Citation Subset:  IM    
Affiliation:
Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 3435 Main St., Farber Hall Rm. #270, Buffalo, NY 14214-3000, USA. msbloom@buffalo.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index
Cholesterol / blood
Cohort Studies
Cross-Sectional Studies
Dichlorodiphenyl Dichloroethylene / metabolism,  toxicity
Environmental Pollutants / adverse effects*,  blood
Fungicides, Industrial / adverse effects,  blood*
Great Lakes Region
Hexachlorobenzene / metabolism,  toxicity
Humans
Insecticides / adverse effects*
Linear Models
Male
Mirex / metabolism,  toxicity
Multivariate Analysis
New York
Pilot Projects
Polychlorinated Biphenyls / metabolism,  toxicity
Smoking
Sports
Thyroxine / blood*
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Fungicides, Industrial; 0/Insecticides; 0/Polychlorinated Biphenyls; 0/Triglycerides; 118-74-1/Hexachlorobenzene; 2385-85-5/Mirex; 57-88-5/Cholesterol; 72-55-9/Dichlorodiphenyl Dichloroethylene; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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