| Exploring the antibacterial and hemolytic activity of shorter- and longer-chain beta-, alpha,beta-, and gamma-peptides, and of beta-peptides from beta2-3-aza- and beta3-2-methylidene-amino acids bearing proteinogenic side chains--a survey. | |
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MedLine Citation:
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PMID: 17191989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antibacterial activities of 31 different beta-, mixed alpha/beta-, and gamma-peptides, as well as of beta-peptides derived from beta2-3-aza- and beta3-2-methylidene-amino acids were assayed against six pathogens (Enterococcus faecalis, Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa), and the results were compared with literature data. The interaction of these peptides with mammalian cells, as modeled by measuring the hemolysis of human erythrocytes, was also investigated. In addition to those peptides designed to fold into amphiphilic helical conformations with positive charges on one face of the helix, one new peptide with hemolytic activity was detected within the sample set. Moreover, it was demonstrated that neither cationic peptides used for membrane translocation (beta3-oligoarginines), nor mixed alpha/beta- or gamma-peptides with somatostatin-mimicking activities display unwanted hemolytic activity. |
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Authors:
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Per I Arvidsson; Neil S Ryder; H Markus Weiss; David F Hook; Jaime Escalante; Dieter Seebach |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemistry & biodiversity Volume: 2 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2006-12-28 Completed Date: 2007-02-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
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Languages: eng Pagination: 401-20 Citation Subset: IM |
Affiliation:
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Uppsala University, Institute of Chemistry, Department of Organic Chemistry, Box 599, SE-75124 Uppsala. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry* Anti-Bacterial Agents / chemistry, pharmacology* Bacteria / classification, drug effects Erythrocytes / drug effects Hemolysis / drug effects* Humans Microbial Sensitivity Tests Peptides / chemistry, pharmacology* Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Anti-Bacterial Agents; 0/Peptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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