| Exploring SOD1 Gene for the Detection of Fetal Down Syndrome. | |
| | |
MedLine Citation:
|
PMID: 22439026 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Fetal cells and circulating cellfree fetal DNA increases in the maternal circulation in women carrying trisomy 21 fetus. METHODS: We attempted the use of superoxide dismutase (SOD-1) gene, which is located at the Down Syndrome Critical Region, to overcome this situation for the prenatal screening of Down syndrome. The prospective of the gene using real-time quantitative polymerase chain reaction was explored. RESULTS: The level of SOD-1 sequences is significantly elevated in the third trimester normal pregnancies (mean = 11728 copies/μl) when compared to the second trimester (mean = 5705.6 copies/μl), (p<0.005) and non pregnant normal women (mean = 3580.2 copies/μl), (p<0.0001). Down syndrome pregnancies have the greatest elevation compared to all the three trimesters of normal singleton pregnancies and twin pregnancies, p<0.05. CONCLUSIONS: These data indicate that a quantitative analysis using a gene associated with a disorder could be used in screening for the prenatal diagnosis of fetal aneuploidies regardless of the sex of the fetus. |
| | |
Authors:
|
Karuppiah Thilakavathy; Rosli Rozita; T P Baskaran |
Related Documents
:
|
1271426 - Prenatal diagnosis of wolman's disease. 10416976 - A case of recurrent congenital fetal anomalies associated with a familial subtelomeric ... 17191256 - Parental decisions to abort or continue a pregnancy following prenatal diagnosis of chr... 17214446 - "all the rest is normal". a pilot study on the communication between physician and pati... 14607056 - Paclitaxel and carboplatin chemotherapy administered during pregnancy for advanced epit... 15675816 - Chemical investigation and authenticity of indian vanilla beans. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of prenatal medicine Volume: 2 ISSN: 1971-3282 ISO Abbreviation: J Prenat Med Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2012-03-22 Completed Date: 2012-08-23 Revised Date: 2013-05-29 |
Medline Journal Info:
|
Nlm Unique ID: 101522906 Medline TA: J Prenat Med Country: Italy |
Other Details:
|
Languages: eng Pagination: 36-9 Citation Subset: - |
Affiliation:
|
Universiti Putra Malaysia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Two-dimensional fetal echocardiography: where we are.
Next Document: Prevention of Neural Tube Defects and proper folate periconceptional supplementation.