Document Detail

Exploring SOD1 Gene for the Detection of Fetal Down Syndrome.
MedLine Citation:
PMID:  22439026     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: Fetal cells and circulating cellfree fetal DNA increases in the maternal circulation in women carrying trisomy 21 fetus.
METHODS: We attempted the use of superoxide dismutase (SOD-1) gene, which is located at the Down Syndrome Critical Region, to overcome this situation for the prenatal screening of Down syndrome. The prospective of the gene using real-time quantitative polymerase chain reaction was explored.
RESULTS: The level of SOD-1 sequences is significantly elevated in the third trimester normal pregnancies (mean = 11728 copies/μl) when compared to the second trimester (mean = 5705.6 copies/μl), (p<0.005) and non pregnant normal women (mean = 3580.2 copies/μl), (p<0.0001). Down syndrome pregnancies have the greatest elevation compared to all the three trimesters of normal singleton pregnancies and twin pregnancies, p<0.05.
CONCLUSIONS: These data indicate that a quantitative analysis using a gene associated with a disorder could be used in screening for the prenatal diagnosis of fetal aneuploidies regardless of the sex of the fetus.
Karuppiah Thilakavathy; Rosli Rozita; T P Baskaran
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of prenatal medicine     Volume:  2     ISSN:  1971-3282     ISO Abbreviation:  J Prenat Med     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2012-03-22     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101522906     Medline TA:  J Prenat Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  36-9     Citation Subset:  -    
Universiti Putra Malaysia.
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