Document Detail

Exploring the "hair growth-wound healing connection": anagen phase promotes wound re-epithelialization.
MedLine Citation:
PMID:  20927125     Owner:  NLM     Status:  In-Process    
When the skin is damaged, a variety of cell types must migrate, proliferate, and differentiate to reform a functional barrier to the external environment. Recent studies have shown that progenitor cells residing in hair follicles (HFs) are able to contribute to this re-epithelialization of wounds in vivo. However, the influence of the hair cycle on wound healing has not previously been addressed. Here, we have exploited spontaneous postnatal hair-cycle synchronicity in mice to systematically examine the influence of the different hair-cycle stages on murine skin wound healing. We report significant acceleration of healing during the anagen phase of HF cycling in vivo, associated with alterations in epithelial, endothelial, and inflammatory cell types. Intriguingly, gene profiling data reveal a clear correlation between the transcription of genes beneficial for wound healing and those upregulated during the anagen phase of the hair cycle in unwounded skin. These findings, which demonstrate a previously unappreciated association between HF cycling and wound healing, reveal numerous molecular correlates for further investigation.
David M Ansell; Jennifer E Kloepper; Helen A Thomason; Ralf Paus; Matthew J Hardman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-07
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  131     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  518-28     Citation Subset:  IM    
Faculty of Life Sciences, University of Manchester, Manchester, UK.
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MeSH Terms
Grant Support
//Biotechnology and Biological Sciences Research Council
Comment In:
J Invest Dermatol. 2011 Feb;131(2):278   [PMID:  21228806 ]
J Invest Dermatol. 2011 Feb;131(2):292-4   [PMID:  21228812 ]

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