Document Detail

Exploring the age of intracranial aneurysms using carbon birth dating: preliminary results.
MedLine Citation:
PMID:  23329209     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: There is a controversy about the time span over which cerebral aneurysms develop. In particular, it is unknown whether collagen in ruptured aneurysms undergoes more rapid turnover than in unruptured aneurysms.(14)C birth dating of collagen could be used to address this question.
METHODS: Aneurysmal domes from patients undergoing surgical treatment for ruptured or unruptured aneurysms were excised. Aneurysmal collagen was isolated and purified after pepsin digestion. Collagen from mouse tendons served as controls. F(14)C levels in collagen were analyzed by accelerator mass spectrometry and correlated with patient age and aneurysm size.
RESULTS: Analysis of 10 aneurysms from 9 patients (6 ruptured, 3 unruptured) revealed an average aneurysm collagen age of <5 years, generally irrespective of patient age and aneurysm size or rupture status. Interestingly, F(14)C levels correlated with patient age as well as aneurysm size in ruptured aneurysm collagen samples.
CONCLUSIONS: Our preliminary data suggest that collagen extracted from intracranial aneurysms generally has a high turnover, associated with aneurysm size and patient age. The correlation of patient age and aneurysm F(14)C levels could explain models of aneurysm development. Although preliminary, our findings may have implications for the biological and structural stability of ruptured and unruptured intracranial aneurysms.
Nima Etminan; Rita Dreier; Bruce A Buchholz; Peter Bruckner; Hans-Jakob Steiger; Daniel Hänggi; R Loch Macdonald
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-17
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  44     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-06-20     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  799-802     Citation Subset:  IM    
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MeSH Terms
Age Factors
Aneurysm, Ruptured / diagnosis*,  metabolism
Carbon / analysis*
Carbon Radioisotopes / diagnostic use
Collagen / chemistry*,  metabolism
Feasibility Studies
Intracranial Aneurysm / diagnosis*,  metabolism
Mass Spectrometry
Middle Aged
Pilot Projects
Radiometric Dating / methods*
Time Factors
Grant Support
P41 GM103483/GM/NIGMS NIH HHS; //Canadian Institutes of Health Research
Reg. No./Substance:
0/Carbon Radioisotopes; 7440-44-0/Carbon; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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