Document Detail


Exploratory assessment of perfluorinated compounds and human thyroid function.
MedLine Citation:
PMID:  19419669     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thyroid hormones play critical roles in human neurodevelopment and adult neurocognitive function. Persistent organohalogen pollutants, such as perfluorinated compounds (PFCs), may interfere with thyroid homeostasis and thus exposures to these compounds might represent risk factors for neurologic and cognitive abnormalities. In this study, serum specimens collected from thirty-one licensed anglers in New York State were analyzed for levels of thyroid stimulating hormone (TSH), free thyroxine (FT(4)), perfluorodecanoic acid (PFDA), perfluorononanoic acid (PFNA), perfluoroheptanoic acid (PFHpA), perfluorohexanesulfonate (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS), perfluorooctanesulfonamide (PFOSA), and perfluoroundecanoic acid (PFUnDA). PFOS and PFOA occurred in the highest concentrations with geometric means of 19.6 ng/mL (95% CI 16.3-23.5) and 1.3 ng/mL (95% CI 1.2-1.5), respectively. In a cross-sectional analysis, no statistically significant associations were detected for PFCs, or their sum, with TSH or FT(4) at alpha=0.05. However, post hoc power analyses, though limited, suggested that moderate increases in sample size, to 86 and 129 subjects, might facilitate 80% power to detect statistically significant associations for FT(4) and PFDA (beta=0.09) and PFUnDA (beta=0.08), respectively. The consumption of sportfish may have contributed to PFDA (r=0.52, P=0.003) and PFUnDA (r=0.40, P=0.025) levels. This preliminary study does not indicate associations between non-occupational PFCs exposures and thyroid function. However, the possibility for weak associations for FT(4) with PFDA and PFUnDA, PFCs measured in low concentrations, is raised. Given the ubiquity of PFCs in the environment and the importance of thyroid function to neurodevelopmental and neurocognitive endpoints, a confirmatory study is warranted.
Authors:
Michael S Bloom; Kurunthachalam Kannan; Henry M Spliethoff; Lin Tao; Kenneth M Aldous; John E Vena
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2009-02-10
Journal Detail:
Title:  Physiology & behavior     Volume:  99     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-5     Citation Subset:  IM    
Copyright Information:
2009 Elsevier Inc. All rights reserved.
Affiliation:
Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, New York 12114, USA. mbloom@albany.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Alkanesulfonic Acids / blood
Analysis of Variance
Decanoic Acids / blood
Environmental Monitoring / methods
Environmental Pollutants / blood*
Female
Fluorocarbons / blood*
Humans
Longitudinal Studies
Male
Middle Aged
New York
Octanoic Acids / blood
Regression Analysis
Retrospective Studies
Thyroid Function Tests
Thyroid Gland / physiology*
Thyrotropin / blood
Thyroxine / blood
Grant Support
ID/Acronym/Agency:
H75-ATH 298338//PHS HHS; U59CCU22339202//PHS HHS
Chemical
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Decanoic Acids; 0/Environmental Pollutants; 0/Fluorocarbons; 0/Octanoic Acids; 1763-23-1/perfluorooctane sulfonic acid; 307-34-6/perfluorooctane; 335-67-1/perfluorooctanoic acid; 335-76-2/perfluorodecanoic acid; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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