| Exploration of novel strategies to enhance monoclonal antibodies targeting. | |
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MedLine Citation:
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PMID: 9195850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper highlights the major obstacles and prospects of antibody targeting for the radioimaging and therapy of human malignant lymphomas and more challenging solid tumors. To improve the therapeutic potential of monoclonal antibodies, we have focused our attention on the development of new and successful methods to augment antibody uptake in the tumor. These approaches include the use of radiolabeled streptavidin to target biotinylated monoclonal antibodies already bound to tumor, pretreatment with vasoactive immunoconjugates, and the use of chemically modified antibodies. Because of the promising preclinical data obtained with these three newer approaches, plans are underway to test them in the clinic. More generally, these approaches are applicable to the use of other monoclonal antibody/tumor systems for the diagnosis and therapy of human cancers and related diseases. |
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Authors:
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L A Khawli; A L Epstein |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) Volume: 41 ISSN: 1125-0135 ISO Abbreviation: Q J Nucl Med Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-07-17 Completed Date: 1997-07-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9512274 Medline TA: Q J Nucl Med Country: ITALY |
Other Details:
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Languages: eng Pagination: 25-35 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Southern California School of Medecine, Los Angeles 90033, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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diagnostic use*,
therapeutic use* Humans Lymphoma / radionuclide imaging, radiotherapy Radioimmunodetection / methods* Radioimmunotherapy / methods* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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