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Exploration of the disease locus by a careful evaluation of the likelihood polynomial for pedigree data.
MedLine Citation:
PMID:  21412249     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It is demonstrated through two case studies that a careful evaluation of the likelihood polynomial results in a more accurate localization of disease locus. The evaluation of the likelihood function as a polynomial enables more flexible exploration of the disease locus. Visualization by a contour plot of the function on a unit square of paternal and maternal recombination fractions along with a superimposed ellipsoid of the Fisher information matrix helps us to find a more accurate localization of the disease locus.Journal of Human Genetics advance online publication, 17 March 2011; doi:10.1038/jhg.2011.24.
Authors:
Yuki Sugaya; Ritei Shibata
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-17
Journal Detail:
Title:  Journal of human genetics     Volume:  -     ISSN:  1435-232X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
School of Fundamental Science and Technology, Keio University, Yokohama, Japan.
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