| Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set. | |
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MedLine Citation:
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PMID: 12819135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cell cycle is one of the most fundamental processes within a cell. Phase-dependent expression and cell-cycle checkpoints require a high level of control. A large number of genes with varying functions and modes of action are responsible for this biology. In a targeted exploration of the FANTOM2-Variable Protein Set, a number of mouse homologs to known cell-cycle regulators as well as novel members of cell-cycle families were identified. Focusing on two prototype cell-cycle families, the cyclins and the NIMA-related kinases (NEKs), we believe we have identified all of the mouse members of these families, 24 cyclins and 10 NEKs, and mapped them to ENSEMBL transcripts. To attempt to globally identify all potential cell cycle-related genes within mouse, the MGI (Mouse Genome Database) assignments for the RIKEN Representative Set (RPS) and the results from two homology-based queries were merged. We identified 1415 genes with possible cell-cycle roles, and 1758 potential paralogs. We comment on the genes identified in this screen and evaluate the merits of each approach. |
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Authors:
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Alistair R R Forrest; Darrin Taylor; Sean Grimmond; ; |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Genome research Volume: 13 ISSN: 1088-9051 ISO Abbreviation: Genome Res. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-23 Completed Date: 2003-08-11 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9518021 Medline TA: Genome Res Country: United States |
Other Details:
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Languages: eng Pagination: 1366-75 Citation Subset: IM |
Affiliation:
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The Institute for Molecular Bioscience, University of Queensland, Queensland Q4072, Australia. a.forrest@imb.uq.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Cell Cycle Proteins / genetics*, physiology Chromosome Segregation / genetics Computational Biology / methods Cyclins / genetics, physiology Databases, Genetic* Drosophila / genetics Female Genes, Insect / genetics, physiology Genes, cdc* Mice Molecular Sequence Data Protein Kinases* Protein-Serine-Threonine Kinases / genetics, metabolism, physiology Protein-Tyrosine Kinases / genetics, physiology |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Cyclins; EC 2.7.-/Protein Kinases; EC 2.7.1.-/NEK7 protein, human; EC 2.7.1.-/NIMA protein kinase; EC 2.7.1.-/NIMA-related kinase 6; EC 2.7.1.-/Nek2 protein, mouse; EC 2.7.1.-/Nek3 protein, mouse; EC 2.7.1.-/Nek7 protein, mouse; EC 2.7.1.37/NEK9 protein, human; EC 2.7.1.37/Nek8 protein, mouse; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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