Document Detail


Exploiting the therapeutic potential of Plasmodium falciparum solute transporters.
MedLine Citation:
PMID:  20392668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammalian transport proteins are essential components of cellular function that have been very successfully exploited as drug targets. Over the past few years, a small but increasing number of Plasmodium transport proteins have been validated as being crucial for parasite survival. This is an essential early step towards identifying new targets for urgently needed antimalarial drugs. Presented here is an overview of our current understanding of the transport processes used by Plasmodium parasites, with an emphasis on their therapeutic potential. It demonstrates the largely untapped potential of targeting these important pathways (including P-type ATPases, ABC transporters and K+ channels) and highlights where these parasites might be most vulnerable to intervention.
Authors:
Henry M Staines; Elvira T Derbyshire; Ksenija Slavic; Amanda Tattersall; Henri Vial; Sanjeev Krishna
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-04-12
Journal Detail:
Title:  Trends in parasitology     Volume:  26     ISSN:  1471-5007     ISO Abbreviation:  Trends Parasitol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966034     Medline TA:  Trends Parasitol     Country:  England    
Other Details:
Languages:  eng     Pagination:  284-96     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Centre for Infection, Division of Cellular and Molecular Medicine, St. George's, University of London, Cranmer Terrace, London, UK. hstaines@sgul.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimalarials / pharmacology*,  therapeutic use
Drug Delivery Systems / methods
Humans
Malaria, Falciparum / drug therapy*,  parasitology
Membrane Transport Proteins / metabolism*
Plasmodium falciparum / metabolism*
Protozoan Proteins / metabolism*
Grant Support
ID/Acronym/Agency:
076441//Wellcome Trust; 077441//Wellcome Trust
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Membrane Transport Proteins; 0/Protozoan Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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