Document Detail

Exploiting the role of TolC in pathogenicity: identification of a bacteriophage for eradication of Salmonella serovars from poultry.
MedLine Citation:
PMID:  20080996     Owner:  NLM     Status:  MEDLINE    
Using a screening procedure, three bacteriophages, ST27, ST29, and ST35, were identified with selective activity for Salmonella enterica serovar Typhimurium (SL1344) but not SL1344 tolC::aph. Overproduction of TolC led to a lower efficiency of plating (EOP), further suggesting that TolC was the target receptor. Activity against other serovars of Salmonella was observed but not against other species of Enterobacteriaceae. This study provides proof of principle that bacteriophages can be active against the outer membrane protein of tripartite resistance-nodulation-division (RND) efflux pumps and so could be used to reduce the numbers of Salmonella cells in animals reared for food production.
Vito Ricci; Laura J V Piddock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-15
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  76     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-24     Completed Date:  2010-05-18     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1704-6     Citation Subset:  IM    
Antimicrobial Agents Research Group, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom.
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MeSH Terms
Bacterial Outer Membrane Proteins / physiology
Poultry Diseases / therapy*
Receptors, Virus / physiology
Salmonella Infections, Animal / therapy*
Salmonella Phages / growth & development*
Salmonella typhimurium / virology*
Virulence Factors / physiology
Reg. No./Substance:
0/Bacterial Outer Membrane Proteins; 0/Receptors, Virus; 0/Virulence Factors

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