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Exploiting mucosal surfaces for the development of mucosal vaccines.
MedLine Citation:
PMID:  21945494     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Mucosal immunity covers a variety of mucosal surfaces susceptible to different pathogens. This review highlights the diversity of mucosal tissues and the unique microenvironments in which an immune response is generated. It argues that tissue-specific factors present throughout mucosal tissues and lymph nodes determine the differentiation into IgA-producing B cells, which in turn determines their migration patterns. Mucosal immunity can therefore be induced when antigen is delivered at any mucosal tissue without the need for specific 'mucosal adjuvants' or targeting to specialised lymphoid structures. Non-oral vaccination strategies directed at alternative and more accessible mucosal tissue sites, may provide new avenues for both mucosal and systemic immunization, and will be greatly facilitated by the use of large animal models.
Authors:
Els N Meeusen
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Publication Detail:
Type:  -     Date:  2011-9-21
Journal Detail:
Title:  Vaccine     Volume:  -     ISSN:  1873-2518     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Biotechnology Research Laboratories, School of Biomedical Sciences, Monash University, Melbourne, VIC 3800, Australia; ARC Centre of Excellence in Structural and Functional Microbial Genomics, Australia.
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