Document Detail

Exploiting micronutrient interaction to optimize biofortification programs: the case for inclusion of selenium and iodine in the HarvestPlus program.
MedLine Citation:
PMID:  15291398     Owner:  NLM     Status:  MEDLINE    
Biofortification of staple food crops with micronutrients by either breeding for higher uptake efficiency or fertilization can be an effective strategy to address widespread dietary deficiency in human populations. Selenium and iodine deficiencies affect a large proportion of the population in countries targeted for biofortification of staple crops with Zn, Fe, and vitamin A, and inclusion of Se and I would be likely to enhance the success of these programs. Interactions between Se and I in the thyroid gland are well established. Moreover, Se appears to have a normalizing effect on certain nutrients in the body. For example, it increases the concentration of Zn and Fe at key sites such as erythrocytes when these elements are deficient, and reduces potentially harmful high Fe concentration in the liver during infection. An important mechanism in Se/Zn interaction is selenoenzyme regulation of Zn delivery from metallothionein to Zn enzymes. More research is needed to determine whether sufficient genetic variability exists within staple crops to enable selection for Se and I uptake efficiency. In addition, bioavailability trials with animals and humans are needed, using varying dietary concentrations of Se, I, Zn, Fe, and vitamin A to elucidate important interactions in order to optimize delivery in biofortification programs.
Graham H Lyons; James C R Stangoulis; Robin D Graham
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  62     ISSN:  0029-6643     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-08-04     Completed Date:  2004-08-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
School of Agriculture and Wine, University of Adelaide, Waite Campus, Urrbrae, South Australia 5064, Australia.
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MeSH Terms
Avitaminosis / prevention & control*
Biological Availability
Iodine / deficiency,  metabolism
Micronutrients / deficiency,  metabolism*
Nutrition Disorders / prevention & control*
Plants, Edible*
Selenium / deficiency,  metabolism
Reg. No./Substance:
0/Micronutrients; 7553-56-2/Iodine; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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