| Exploiting cell surface thiols to enhance cellular uptake. | |
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MedLine Citation:
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PMID: 22260747 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Efficient cellular delivery is one of the key issues that has hampered the therapeutic development of novel synthetic biomolecules such as oligonucleotides, peptides and nanoparticles. The highly specialized cellular plasma membrane specifically internalizes compounds through tightly regulated mechanisms. It is possible to exploit these natural mechanisms of cellular uptake with rationally designed reagents. Here, we discuss how thiol groups (-SH) naturally present on the cell surface (exofacial thiols) can be used to enhance cellular association and internalization of various materials bearing thiol-reactive groups in their structure. We propose that such thiol modifications should be considered in future design of synthetic biomolecules for optimized cellular delivery. |
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Authors:
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Adrian G Torres; Michael J Gait |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-17 |
Journal Detail:
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Title: Trends in biotechnology Volume: - ISSN: 1879-3096 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8310903 Medline TA: Trends Biotechnol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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