| Exploiting phenotypic plasticity for the treatment of hepatopulmonary shunting in Abernethy malformation. | |
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MedLine Citation:
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PMID: 20399112 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An 11-year-old boy presented with exercise intolerance due to chronic hypoxemia. Work-up revealed a diagnosis of hepatopulmonary syndrome (HPS) secondary to a congenital extrahepatic portal-venous shunt (Abernethy malformation). Plasticity in the developing liver was exploited as a strategy for the treatment of HPS. With use of a staged endovascular approach, the portosystemic vascular circuitry was modified in a manner that facilitated progressive growth and development of the severely hypoplastic and underdeveloped intrahepatic portal venous system. After completion of the final procedure, the patient's intrahepatic portal veins were normal in appearance; 2 months later, signs and symptoms of HPS completely resolved. The patient remains free of HPS stigmata after 2 years. |
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Authors:
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Michael D Kuo; Franklin J Miller; Joel E Lavine; Michael Peterson; Michael Finch |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-04-15 |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 21 ISSN: 1535-7732 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 917-22 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Vascular and Interventional Radiology, University of California Los Angeles, David Geffen School of Medicine, 10833 LeConte Ave, Mail Code CHS 172115, Los Angeles, CA 90095, USA. michaelkuo@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Hepatopulmonary Syndrome / surgery* Humans Male Portal Vein / abnormalities*, surgery* Pulmonary Veins / abnormalities*, surgery* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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