Document Detail

Exploitation of the intestinal microflora by the parasitic nematode Trichuris muris.
MedLine Citation:
PMID:  20538949     Owner:  NLM     Status:  MEDLINE    
The inhabitants of the mammalian gut are not always relatively benign commensal bacteria but may also include larger and more parasitic organisms, such as worms and protozoa. At some level, all these organisms are capable of interacting with each other. We found that successful establishment of the chronically infecting parasitic nematode Trichuris muris in the large intestine of mice is dependent on microflora and coincident with modulation of the host immune response. By reducing the number of bacteria in the host animal, we significantly reduced the number of hatched T. muris eggs. Critical interactions between bacteria (microflora) and parasites (macrofauna) introduced a new dynamic to the intestinal niche, which has fundamental implications for our current concepts of intestinal homeostasis and regulation of immunity.
K S Hayes; A J Bancroft; M Goldrick; C Portsmouth; I S Roberts; R K Grencis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  328     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-06-22     Revised Date:  2013-03-28    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1391-4     Citation Subset:  IM    
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.
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MeSH Terms
Adaptive Immunity
Adhesins, Escherichia coli / metabolism
Anti-Bacterial Agents / pharmacology
Antibodies, Helminth / biosynthesis
Bacterial Physiological Phenomena*
Cecum / microbiology,  parasitology
Cytokines / metabolism
Escherichia coli / physiology
Fimbriae Proteins / metabolism
Fimbriae, Bacterial / physiology
Fluoroquinolones / pharmacology
Host-Parasite Interactions
Intestine, Large / microbiology*,  parasitology*
Mice, Inbred AKR
Mice, Inbred C57BL
Mice, SCID
Ovum / physiology
Th2 Cells / immunology
Trichuriasis / immunology,  microbiology,  parasitology*
Trichuris / embryology,  physiology*
Grant Support
083620//Wellcome Trust; 083620Z//Wellcome Trust; G0601205//Medical Research Council; //Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Adhesins, Escherichia coli; 0/Anti-Bacterial Agents; 0/Antibodies, Helminth; 0/Cytokines; 0/Fluoroquinolones; 0/fimH protein, E coli; 147680-16-8/Fimbriae Proteins; 93106-60-6/enrofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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