Document Detail


Exploitation of evolutionarily conserved amoeba and mammalian processes by Legionella.
MedLine Citation:
PMID:  22494803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Legionella pneumophila proliferates within various protists and metazoan cells, where a cadre of ∼300 effectors is injected into the host cell by the defect in organelle trafficking/intracellular multiplication (Dot/Icm) type IVB translocation system. Interkingdom horizontal gene transfer of genes of protists and their subsequent convergent evolution to become translocated effectors has probably enabled L. pneumophila to adapt to the intracellular life within various protists and metazoan cells through exploitation of evolutionarily eukaryotic processes, such as endoplasmic reticulum-to-Golgi vesicle traffic, phosphoinositol metabolism, AMPylation, deAMPylation, prenylation, polyubiquitination, proteasomal degradation and cytosolic amino- and oligo-peptidases. This is highlighted by the ankyrin B (AnkB) F-box effector that exploits multiple conserved eukaryotic machineries to generate high levels of free amino acids as sources of carbon and energy essential for intracellular proliferation in protists and metazoan cells and for manifestation of pulmonary disease in mammals.
Authors:
Tasneem Al-Quadan; Christopher T Price; Yousef Abu Kwaik
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-09
Journal Detail:
Title:  Trends in microbiology     Volume:  20     ISSN:  1878-4380     ISO Abbreviation:  Trends Microbiol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-09-20     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  9310916     Medline TA:  Trends Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  299-306     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Amoeba / microbiology*
Animals
Humans
Legionella pneumophila / growth & development,  physiology*
Mammals / microbiology*
Models, Biological
Grant Support
ID/Acronym/Agency:
R01 AI069321/AI/NIAID NIH HHS; R01 AI069321-05/AI/NIAID NIH HHS; R01AI069321/AI/NIAID NIH HHS; R01AI43965/AI/NIAID NIH HHS
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