Document Detail

Exploitation of the ubiquitin system by invading bacteria.
MedLine Citation:
PMID:  20977569     Owner:  NLM     Status:  MEDLINE    
A variety of bacterial intracellular pathogens target the host cell ubiquitin system during invasion, a process that involves transient but fundamental changes in the actin cytoskeleton and plasma membrane. These changes are induced by bacterial proteins, which can be surface associated, secreted or injected directly into the host cell. Here, the invasion strategies of two extensively studied intracellular bacteria, Salmonella enterica serovar Typhimurium and Listeria monocytogenes, are used to illustrate some of the diverse ways by which bacterial pathogens intersect the host cell ubiquitin pathway.
Olivia Steele-Mortimer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review     Date:  2010-11-24
Journal Detail:
Title:  Traffic (Copenhagen, Denmark)     Volume:  12     ISSN:  1600-0854     ISO Abbreviation:  Traffic     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-10     Completed Date:  2011-04-21     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  100939340     Medline TA:  Traffic     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  162-9     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA.
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MeSH Terms
Actins / metabolism*
Bacteria / metabolism*
Cell Membrane / metabolism
Cytoskeleton / metabolism
Ubiquitin / metabolism*
Grant Support
Reg. No./Substance:
0/Actins; 0/Ubiquitin

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