| Explanatory and pragmatic attitudes in therapeutical trials. | |
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MedLine Citation:
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PMID: 19348976 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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It is the thesis of this paper that most therapeutic trials are inadequately formulated, and this from the earliest stages of their conception. Their inadequacy is basic, in that the trials may be aimed at the solution of one or other of two radically different kinds of problem; the resulting ambiguity affects the definition of the treatments, the assessment of the results, the choice of subjects and the way in which the treatments are compared. It often occurs that one type of approach is ethically less defensible than the other, or may even be ruled out altogether on ethical grounds. We postpone consideration of this aspect of the question until a later section. |
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Authors:
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Daniel Schwartz; Joseph Lellouch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical epidemiology Volume: 62 ISSN: 1878-5921 ISO Abbreviation: J Clin Epidemiol Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-07 Completed Date: 2009-06-29 Revised Date: 2011-10-11 |
Medline Journal Info:
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Nlm Unique ID: 8801383 Medline TA: J Clin Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 499-505 Citation Subset: - |
Affiliation:
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Unité de Recherches Statistiques, Institut National de la Santé et de la Recherche Medicale, Villejuif, France. |
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Descriptor/Qualifier:
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Republished from:
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J Chronic Dis. 1967 Aug;20(8):637-48
[PMID:
4860352
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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