| Explained variance for blood gases in a population with COPD. | |
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MedLine Citation:
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PMID: 21812941 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Variation of blood gas levels in chronic obstructive pulmonary disease (COPD) patients has not been extensively reported and there is limited knowledge about predictors of chronic respiratory failure in COPD patients. Objectives: The aim of this study was to identify predictors of hypoxemia, hypercapnia and increased alveolar-arterial oxygen difference in COPD patients. We hypothesized that prediction of arterial blood gases will be improved in multivariate models including measurements of lung function, anthropometry and systemic inflammation. Methods: A cross-sectional sample of 382 Norwegian COPD patients, age 40-76, Global Initiative for Chronic Obstructive Lung Disease stage II-IV, with a smoking history of at least 10 pack-years, underwent extensive measurements, including medical examination, arterial blood gases, systemic inflammatory markers, spirometry, plethysmography, respiratory impedance and bioelectrical impedance. Possible predictors of arterial oxygen (PaO(2) ), arterial carbon dioxide (PaCO(2) ) and alveolar-arterial oxygen difference (AaO(2) ) were analyzed with both bivariate and multiple regression methods. Results: We found that various lung function measurements were significantly associated with PaO2, PaCO(2) and AaO(2) . In addition, heart rate and Fat Mass Index were predictors of PaO(2) and AaO(2) , while heart failure and current smoking status were associated with PaCO(2) . The explained variance (R(2) ) in the final multivariate regression models was 0.14-0.20. Conclusions: With a wide assortment of possible clinical predictors, we could explain 14-20% of the variation in blood gas measurements in COPD patients. Please cite this paper as: Saure EW, Eagan TML, Jensen RL, Voll-Aanerud M, Aukrust P, Bakke PS and Hardie JA. Explained variance for blood gases in a population with COPD. Clin Respir J 2011; DOI:10.1111/j.1752-699X.2011.00248.x. |
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Authors:
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Eirunn Waatevik Saure; Tomas Mikal Lind Eagan; Robert Leroy Jensen; Marianne Voll-Aanerud; Pål Aukrust; Per Sigvald Bakke; Jon Andrew Hardie |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-3 |
Journal Detail:
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Title: The clinical respiratory journal Volume: - ISSN: 1752-699X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101315570 Medline TA: Clin Respir J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Section of Pulmonary Medicine, Institute of Medicine, University of Bergen, Bergen, Norway Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway Internal Medicine, Pulmonary Division, University of Utah, Salt Lake City, UT, USA Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway Faculty of Medicine, University of Oslo, Oslo, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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