Document Detail

Expiratory flow limitation in patients with pleural effusion.
MedLine Citation:
PMID:  17396027     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Expiratory flow limitation (EFL) is one of the main mechanisms contributing to dyspnea in patients with chronic obstructive pulmonary disease but has not been explored in patients with pleural effusion. OBJECTIVES: It was the aim of this study to determine whether patients with pleural effusion exhibit EFL and to investigate the effect of therapeutic thoracentesis on EFL. PATIENTS AND METHODS: The study was performed on 21 patients with pleural effusion who were subjected to thoracentesis and measurement of pleural pressure (PP). Spirometry and estimation of flow limitation by the negative expiratory pressure technique were performed before and after thoracentesis. RESULTS: Statistically significant differences were observed in all spirometric parameters. No correlation between the increase in lung volumes and flows and any of the aspirated fluid parameters was observed. Before thoracentesis, 14 out of 21 patients were flow limited, compared with 7 patients after thoracentesis (chi(2) = 6.151, p = 0.013). Mean values of flow limitation before and after thoracentesis differed significantly. The decrease in flow limitation did not correlate with the increase in the spirometric parameters, the aspirated fluid volume or PP decrease. CONCLUSIONS: In the majority of patients with pleural effusion, flow limitation improves after thoracentesis. Flow limitation may be a contributing factor to the sensation of dyspnea in these patients.
D Spyratos; L Sichletidis; K Manika; T Kontakiotis; D Chloros; D Patakas
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Publication Detail:
Type:  Journal Article     Date:  2007-03-30
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  74     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-02     Completed Date:  2007-10-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  572-8     Citation Subset:  IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Pulmonary Clinic, G. Papanicolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
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MeSH Terms
Forced Expiratory Flow Rates
Forced Expiratory Volume
Middle Aged
Pleural Effusion / physiopathology*,  therapy
Supine Position / physiology

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