Document Detail

Expert second-opinion pathology review of lymphoma in the era of the World Health Organization classification.
MedLine Citation:
PMID:  21415238     Owner:  NLM     Status:  Publisher    
BACKGROUND: The World Health Organization (WHO) classification of hematologic malignancies, published in 2000, was designed to improve diagnostic accuracy by incorporating the latest in scientific understanding. The impact of the WHO classification on the frequency of diagnostic discrepancy in lymphoma is unknown. METHODS: We reviewed all second-opinion pathology of lymphoma at our National Cancer Institute-designated Comprehensive Cancer Center (NCI-CCC) from January to June 2001 and from January to June 2006. Discrepancies between submitted and second-opinion diagnoses were scored based upon an a priori grading schema. RESULTS: Major diagnostic revision was rendered in 65 of 365 cases (17.8%) in 2001 and 58 of 354 (16.4%) in 2006 (P = NS). Including cases reviewed and revised beforehand at another NCI-CCC, rates of major diagnostic revision were 21.4% and 18.6%, respectively (P = NS). Discrepancy rates varied by diagnosis, from Hodgkin lymphoma (10%) to Burkitt's lymphoma (75%). No association was seen for age, gender, race/ethnicity, biopsy type, or nature of referring center. CONCLUSIONS: Clinically meaningful diagnostic revision occurs frequently with expert pathology review for a diagnosis of lymphoma. Despite the WHO classification, rates of diagnostic revision at our institution in 2001 and 2006 did not differ significantly. Given the potential harm from misdiagnosis, expert hematopathology review should be considered the standard of care.
M J Matasar; W Shi; J Silberstien; O Lin; K J Busam; J Teruya-Feldtein; D A Filippa; A D Zelenetz; A Noy
Related Documents :
8425388 - A persuasion therapy for panic disorder in old japanese medical literature.
1864208 - Secretory diarrhea following a dog bite.
6746198 - Reflections on dora: the case of hysteria.
13130088 - Chigger mite infestation.
3998638 - Intralaryngeal arytenoidectomy. a report of six cases.
15923098 - A case of osteoma with cholesteatoma in the external auditory canal.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-17
Journal Detail:
Title:  Annals of oncology : official journal of the European Society for Medical Oncology / ESMO     Volume:  -     ISSN:  1569-8041     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007735     Medline TA:  Ann Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Lymphoma Service, Department of Medicine.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Efficacy of capecitabine versus 5-fluorouracil in colorectal and gastric cancers: a meta-analysis of...
Next Document:  Thiazolidinediones and metformin associated with improved survival of diabetic prostate cancer patie...